From Bench-Top to Bedside: A prospective In vitro Antibiotic Combination Testing (iACT) service to guide the selection of rationally optimized antimicrobial combinations against Extensively Drug Resistant (XDR) Gram Negative Bacteria (GNB)

• Main Authors: Cai Y., Chua N.G., Lim T.-P., Teo J.Q.-M., Lee W., Kurup A., Koh T.-H., Tan T.-T., Kwa A.L.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Public Library of Science 2020
• Subjects: antibiotic resistance; Article; bloodstream infection; clinical feature; controlled study; drug screening; drug selectivity; extensively drug resistant gram negative bacteria; feasibility study; Gram negative bacterium; in vitro antibiotic combination testing; mortality; nonhuman; outcome assessment; pneumonia; prescription; process optimization; retrospective study; Singapore; combination drug therapy; demography; dose response; drug effects; female; Gram-Negative Bacterial Infections; hospital mortality; human; male; microbial sensitivity test; microbiology; middle aged; multidrug resistance; prospective study; translational research; antiinfective agent; Anti-Bacterial Agents; Demography; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Female; Hospital Mortality; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Prospective Studies; Translational Medical Research
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165744
• Institution: National University of Singapore

10.1371/journal.pone.0158740