Characterization of a polyethylene glycol-amphotericin B conjugate loaded with free AMB for improved antifungal efficacy

• Main Authors: Tan T.R.M., Hoi K.M., Zhang P., Ng S.K.
• Other Authors: ANATOMY
• Format: Article
• Published: Public Library of Science 2020
• Subjects: amphotericin B; macrogol; antifungal agent; macrogol derivative; antifungal activity; antifungal susceptibility; Article; Aspergillus fumigatus; Candida albicans; chemical reaction; complex formation; controlled study; Cryptococcus neoformans; cytotoxicity; drug dosage form comparison; drug efficacy; drug formulation; drug safety; drug solubility; fungal strain; high performance liquid chromatography; human; human cell; in vitro study; incubation time; mammal cell; mass spectrometry; matrix assisted laser desorption ionization time of flight mass spectrometry; minimum inhibitory concentration; nonhuman; particle size; photon correlation spectroscopy; reversed phase liquid chromatography; Saccharomyces cerevisiae; size exclusion chromatography; therapeutic index; ultraviolet spectroscopy; analogs and derivatives; cell line; chemistry; drug effects; HEK293 cell line; medicinal chemistry; microbial sensitivity test; solubility; Amphotericin B; Antifungal Agents; Cell Line; Chemistry, Pharmaceutical; Chromatography, Gel; Chromatography, High Pressure Liquid; HEK293 Cells; Humans; Microbial Sensitivity Tests; Particle Size; Polyethylene Glycols; Solubility
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165750
• Institution: National University of Singapore

10.1371/journal.pone.0152112