Intra-operative cerebrospinal fluid sampling versus post-operative lumbar puncture for detection of leptomeningeal disease in malignant paediatric brain tumours

• Main Authors: Low S.Y.Y., Wei C.M., Chang K.T.E., Huak C.Y., Ping N.L., Tew S.W., Low D.C.Y.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Published: Public Library of Science 2020
• Subjects: adolescent; anesthesia induction; Article; atypical teratoid rhabdoid tumour; brain cancer; brain disease; cerebrospinal fluid analysis; child; childhood cancer; clinical article; cohort analysis; controlled study; cytology; disease association; ependymoma; female; germ cell tumor; human; human tissue; intermethod comparison; intraoperative monitoring; leptomeningeal disease; lumbar puncture; male; medulloblastoma; neurosurgery; nuclear magnetic resonance imaging; outcome assessment; pineoblastoma; postoperative period; retrospective study; sensitivity and specificity; arachnoid; brain tumor; cell count; cerebrospinal fluid; comparative study; diagnosis; diagnostic imaging; evaluation study; false negative result; infant; intraoperative period; neuroimaging; pathology; pia mater; preschool child; procedures; specimen handling; spine; tumor invasion; Adolescent; Arachnoid; Brain Neoplasms; Cell Count; Cerebrospinal Fluid; Child; Child, Preschool; False Negative Reactions; Female; Humans; Infant; Intraoperative Period; Magnetic Resonance Imaging; Male; Neoplasm Invasiveness; Neuroimaging; Pia Mater; Retrospective Studies; Sensitivity and Specificity; Specimen Handling; Spinal Puncture; Spine
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165901
• Institution: National University of Singapore

10.1371/journal.pone.0196696