Intra-cameral level of ganciclovir gel, 0.15% following topical application for cytomegalovirus anterior segment infection: A pilot study

• Main Authors: Waduthantri S., Zhou L., Chee S.-P.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Public Library of Science 2020
• Subjects: ganciclovir; antivirus agent; adult; aged; anterior eye segment; aqueous humor; Article; central corneal thickness; clinical article; clinical trial; cytomegalovirus anterior segment infection; cytomegalovirus infection; disease activity; drug penetration; drug tissue level; endotheliitis; female; human; ID50; intervention study; iridocyclitis; lacrimal fluid level; liquid chromatography-mass spectrometry; male; middle aged; patient compliance; pilot study; reverse transcription polymerase chain reaction; Singapore; very elderly; viral eye infection; virus load; Cytomegalovirus; genetics; intraocular drug administration; liquid chromatography; pathology; prospective study; real time polymerase chain reaction; tandem mass spectrometry; Administration, Ophthalmic; Adult; Aged; Aged, 80 and over; Anterior Eye Segment; Antiviral Agents; Chromatography, Liquid; Cytomegalovirus Infections; Female; Ganciclovir; Humans; Male; Middle Aged; Pilot Projects; Prospective Studies; Real-Time Polymerase Chain Reaction; Tandem Mass Spectrometry
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165913
• Institution: National University of Singapore

10.1371/journal.pone.0191850