Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain

10.1371/journal.pone.0090024

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Main Authors:	Schlichter L.C., Jiang J., Wang J., Newell E.W., Tsui F.W.L., Lam D.
Other Authors:	MICROBIOLOGY AND IMMUNOLOGY
Format:	Article
Published:	Public Library of Science 2020
Subjects:	cyclic nucleotide potassium channel potassium channel hEAG potassium channel HERG protein tyrosine kinase protein tyrosine phosphatase SHP 1 unclassified drug amino acid sequence article controlled study enzyme activation enzyme activity human human cell immunoreceptor tyrosine based inhibition motif nucleotide binding site nucleotide sequence potassium current protein phosphorylation regulatory mechanism Action Potentials Amino Acid Sequence Animals Conserved Sequence Cyclic AMP Ether-A-Go-Go Potassium Channels Gene Expression Regulation HEK293 Cells Humans Mice Molecular Sequence Data Patch-Clamp Techniques Peptides Protein Binding Protein Structure, Tertiary Protein Tyrosine Phosphatase, Non-Receptor Type 6 Pyrazoles Pyrimidines Rats Sequence Homology, Amino Acid Signal Transduction src-Family Kinases
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/165956
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1659562024-11-09T20:55:06Z Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain Schlichter L.C. Jiang J. Wang J. Newell E.W. Tsui F.W.L. Lam D. MICROBIOLOGY AND IMMUNOLOGY cyclic nucleotide potassium channel potassium channel hEAG potassium channel HERG protein tyrosine kinase protein tyrosine phosphatase SHP 1 unclassified drug amino acid sequence article controlled study enzyme activation enzyme activity human human cell immunoreceptor tyrosine based inhibition motif nucleotide binding site nucleotide sequence potassium current protein phosphorylation regulatory mechanism Action Potentials Amino Acid Sequence Animals Conserved Sequence Cyclic AMP Ether-A-Go-Go Potassium Channels Gene Expression Regulation HEK293 Cells Humans Mice Molecular Sequence Data Patch-Clamp Techniques Peptides Protein Binding Protein Structure, Tertiary Protein Tyrosine Phosphatase, Non-Receptor Type 6 Pyrazoles Pyrimidines Rats Sequence Homology, Amino Acid Signal Transduction src-Family Kinases 10.1371/journal.pone.0090024 PLoS ONE 9 2 e90024 2020-03-26T06:43:11Z 2020-03-26T06:43:11Z 2014 Article Schlichter L.C., Jiang J., Wang J., Newell E.W., Tsui F.W.L., Lam D. (2014). Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain. PLoS ONE 9 (2) : e90024. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0090024 19326203 https://scholarbank.nus.edu.sg/handle/10635/165956 Public Library of Science Unpaywall 20200320
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	cyclic nucleotide potassium channel potassium channel hEAG potassium channel HERG protein tyrosine kinase protein tyrosine phosphatase SHP 1 unclassified drug amino acid sequence article controlled study enzyme activation enzyme activity human human cell immunoreceptor tyrosine based inhibition motif nucleotide binding site nucleotide sequence potassium current protein phosphorylation regulatory mechanism Action Potentials Amino Acid Sequence Animals Conserved Sequence Cyclic AMP Ether-A-Go-Go Potassium Channels Gene Expression Regulation HEK293 Cells Humans Mice Molecular Sequence Data Patch-Clamp Techniques Peptides Protein Binding Protein Structure, Tertiary Protein Tyrosine Phosphatase, Non-Receptor Type 6 Pyrazoles Pyrimidines Rats Sequence Homology, Amino Acid Signal Transduction src-Family Kinases
spellingShingle	cyclic nucleotide potassium channel potassium channel hEAG potassium channel HERG protein tyrosine kinase protein tyrosine phosphatase SHP 1 unclassified drug amino acid sequence article controlled study enzyme activation enzyme activity human human cell immunoreceptor tyrosine based inhibition motif nucleotide binding site nucleotide sequence potassium current protein phosphorylation regulatory mechanism Action Potentials Amino Acid Sequence Animals Conserved Sequence Cyclic AMP Ether-A-Go-Go Potassium Channels Gene Expression Regulation HEK293 Cells Humans Mice Molecular Sequence Data Patch-Clamp Techniques Peptides Protein Binding Protein Structure, Tertiary Protein Tyrosine Phosphatase, Non-Receptor Type 6 Pyrazoles Pyrimidines Rats Sequence Homology, Amino Acid Signal Transduction src-Family Kinases Schlichter L.C. Jiang J. Wang J. Newell E.W. Tsui F.W.L. Lam D. Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain
description	10.1371/journal.pone.0090024
author2	MICROBIOLOGY AND IMMUNOLOGY
author_facet	MICROBIOLOGY AND IMMUNOLOGY Schlichter L.C. Jiang J. Wang J. Newell E.W. Tsui F.W.L. Lam D.
format	Article
author	Schlichter L.C. Jiang J. Wang J. Newell E.W. Tsui F.W.L. Lam D.
author_sort	Schlichter L.C.
title	Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain
title_short	Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain
title_full	Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain
title_fullStr	Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain
title_full_unstemmed	Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain
title_sort	regulation of herg and heag channels by src and by shp-1 tyrosine phosphatase via an itim region in the cyclic nucleotide binding domain
publisher	Public Library of Science
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/165956
_version_	1821221251709927424

Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain

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