Multiplex serum protein analysis identifies novel biomarkers of advanced fibrosis in patients with chronic liver disease with the potential to improve diagnostic accuracy of established biomarkers

• Main Authors: Irvine K.M., Wockner L.F., Hoffmann I., Horsfall L.U., Fagan K.J., Bijin V., Lee B., Clouston A.D., Lampe G., Connolly J.E., Powell E.E.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: Public Library of Science 2020
• Subjects: adipocytokine; alanine aminotransferase; alpha fetoprotein; aspartate aminotransferase; biological marker; cytokine; hyaluronic acid; interleukin 8; interstitial collagenase; matrilysin; platelet derived growth factor AA; procollagen type 3 aminopropeptide; tissue inhibitor of metalloproteinase 1; plasma protein; adult; age; analytical parameters; Article; aspartate aminotransferase platelet ratio index; body mass; chronic liver disease; cohort analysis; controlled study; cross-sectional study; diabetes mellitus; diagnostic accuracy; diagnostic test accuracy study; disease activity; disease association; disease severity; enzyme linked immunosorbent assay; fatty liver; female; hepatitis; human; immunoassay analyzer; liver biopsy; liver fibrosis; major clinical study; male; middle aged; predictive value; protein analysis; protein blood level; receiver operating characteristic; retrospective study; sensitivity and specificity; blood; liver cirrhosis; reproducibility; severity of illness index; statistical model; Adult; Biomarkers; Blood Proteins; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Liver Cirrhosis; Logistic Models; Male; Middle Aged; Reproducibility of Results; Retrospective Studies; Severity of Illness Index
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/166034
• Institution: National University of Singapore

10.1371/journal.pone.0167001