Bofu-Tsu-Shosan, an Oriental Herbal Medicine, Exerts a Combinatorial Favorable Metabolic Modulation Including Antihypertensive Effect on a Mouse Model of Human Metabolic Disorders with Visceral Obesity

• Main Authors: Azushima K., Tamura K., Wakui H., Maeda A., Ohsawa M., Uneda K., Kobayashi R., Kanaoka T., Dejima T., Fujikawa T., Yamashita A., Toya Y., Umemura S.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Public Library of Science 2020
• Subjects: adiponectin; bofu tsu shosan; ghrelin; herbaceous agent; low density lipoprotein cholesterol; peroxisome proliferator activated receptor alpha; peroxisome proliferator activated receptor gamma; plasma acylated ghrelin; unclassified drug; uncoupling protein 1; animal experiment; animal model; animal tissue; antihypertensive activity; article; brown adipose tissue; cell size; cholesterol blood level; controlled study; drug mechanism; food intake; gene expression; heart rate; herbal medicine; hypertension; intraabdominal fat; long term care; male; metabolic disorder; mouse; non insulin dependent diabetes mellitus; nonhuman; obesity; protein blood level; rectum temperature; systolic blood pressure; tissues; visceral obesity; weight gain; white adipose tissue; Animals; Blood Pressure; Disease Models, Animal; Drugs, Chinese Herbal; Herbal Medicine; Humans; Ion Channels; Metabolic Diseases; Mice; Mitochondrial Proteins; Obesity, Abdominal
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/166190
• Institution: National University of Singapore

10.1371/journal.pone.0075560