Active Suppression Induced by Repetitive Self-Epitopes Protects against EAE Development

• Main Authors: Puentes F., Dickhaut K., Hofstätter M., Falk K., Röetzschke O.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: Public Library of Science 2020
• Subjects: epitope; Freund adjuvant; immunosuppressive agent; myelin proteolipid protein[139-151]; oligomer; serylvalylserylserylphenylalanylglutamylarginylphenylalanylglutamylisoleucylphenylalalnylprolyllysine; synthetic peptide; T lymphocyte antigen; transforming growth factor beta; tumor necrosis factor alpha; unclassified drug; adoptive transfer; allergic encephalomyelitis; animal cell; animal experiment; animal model; animal tissue; antigen specificity; article; controlled study; cytokine production; disease control; ex vivo study; female; immunological tolerance; immunoprophylaxis; immunosuppressive treatment; in vivo study; lymphocyte proliferation; mouse; multiple sclerosis; nonhuman; oligomerization; treatment outcome; Adoptive Transfer; Animals; Autoantigens; Cell Proliferation; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Epitopes, T-Lymphocyte; Female; Immunosuppression; Mice; Myelin Proteolipid Protein; Peptide Fragments; Protein Multimerization; Protein Structure, Quaternary; T-Lymphocytes; Animalia; Mus
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/166574
• Institution: National University of Singapore

10.1371/journal.pone.0064888