Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in Alzheimer's disease with and without cerebrovascular disease

• Main Authors: Ji F., Pasternak O., Liu S., Loke Y.M., Choo B.L., Hilal S., Xu X., Ikram M.K., Venketasubramanian N., Chen C.L.-H., Zhou J.
• Other Authors: PHARMACOLOGY
• Format: Article
• Published: 2020
• Subjects: aged; Alzheimer disease; Article; attention; brain water; cerebrovascular disease; cognition assessment; cognitive defect; controlled study; dementia; diffusion tensor imaging; disease association; disease classification; disease course; disease severity; executive function; extracellular fluid; female; human; image analysis; language disability; major clinical study; male; motor performance; multiinfarct dementia; neurologic examination; priority journal; tissue structure; visual stimulation; voxel based morphometry; white matter lesion; body water; brain; cognition; cohort analysis; complication; dementia assessment; diagnostic imaging; diffusion weighted imaging; extracellular space; procedures; psychology; severity of illness index; white matter; Aged; Alzheimer Disease; Body Water; Brain; Cerebrovascular Disorders; Cognition; Cognitive Dysfunction; Cohort Studies; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; Extracellular Space; Female; Humans; Male; Mental Status and Dementia Tests; Severity of Illness Index; White Matter
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/173776
• Institution: National University of Singapore

10.1186/s13195-017-0292-4