VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim

10.18632/oncotarget.21988

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Main Authors:	Mustafa, N, Ting Lee, J.X, Adina Nee, H.F, Bi, C, Chung, T.-H, Hart, S, Chng, W.J
Other Authors:	MEDICINE
Format:	Article
Published:	2020
Subjects:	5 (9 isopropyl 8 methyl 2 morpholino 9h purin 6 yl) 2 pyrimidinamine beta catenin BIM protein bortezomib caspase 3 cyclin D2 cyclin dependent kinase 4 cytochrome c dexamethasone dickkopf 1 protein mammalian target of rapamycin melphalan messenger RNA nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase panobinostat phosphatidylinositol 3 kinase protein Bax protein bcl xl protein kinase B protein S6 survivin Akt signaling animal experiment animal model antineoplastic activity apoptosis Article cancer inhibition cell viability cellular distribution concentration response controlled study cytosol down regulation drug cytotoxicity drug effect drug efficacy drug mechanism drug potentiation enzyme activation enzyme activity female G1 phase cell cycle checkpoint gene expression profiling gene expression regulation gene silencing human human cell IC50 in vivo study mouse multiple myeloma multiple myeloma cell line nonhuman protein cleavage protein expression protein phosphorylation RARRES3 gene therapeutic index tumor suppressor gene tumor volume tumor xenograft upregulation
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/173800
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1738002024-11-13T08:41:06Z VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim Mustafa, N Ting Lee, J.X Adina Nee, H.F Bi, C Chung, T.-H Hart, S Chng, W.J MEDICINE CANCER SCIENCE INSTITUTE OF SINGAPORE 5 (9 isopropyl 8 methyl 2 morpholino 9h purin 6 yl) 2 pyrimidinamine beta catenin BIM protein bortezomib caspase 3 cyclin D2 cyclin dependent kinase 4 cytochrome c dexamethasone dickkopf 1 protein mammalian target of rapamycin melphalan messenger RNA nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase panobinostat phosphatidylinositol 3 kinase protein Bax protein bcl xl protein kinase B protein S6 survivin Akt signaling animal experiment animal model antineoplastic activity apoptosis Article cancer inhibition cell viability cellular distribution concentration response controlled study cytosol down regulation drug cytotoxicity drug effect drug efficacy drug mechanism drug potentiation enzyme activation enzyme activity female G1 phase cell cycle checkpoint gene expression profiling gene expression regulation gene silencing human human cell IC50 in vivo study mouse multiple myeloma multiple myeloma cell line nonhuman protein cleavage protein expression protein phosphorylation RARRES3 gene therapeutic index tumor suppressor gene tumor volume tumor xenograft upregulation 10.18632/oncotarget.21988 Oncotarget 8 60 101847-101864 2020-09-01T00:57:32Z 2020-09-01T00:57:32Z 2017 Article Mustafa, N, Ting Lee, J.X, Adina Nee, H.F, Bi, C, Chung, T.-H, Hart, S, Chng, W.J (2017). VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim. Oncotarget 8 (60) : 101847-101864. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.21988 19492553 https://scholarbank.nus.edu.sg/handle/10635/173800 Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	5 (9 isopropyl 8 methyl 2 morpholino 9h purin 6 yl) 2 pyrimidinamine beta catenin BIM protein bortezomib caspase 3 cyclin D2 cyclin dependent kinase 4 cytochrome c dexamethasone dickkopf 1 protein mammalian target of rapamycin melphalan messenger RNA nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase panobinostat phosphatidylinositol 3 kinase protein Bax protein bcl xl protein kinase B protein S6 survivin Akt signaling animal experiment animal model antineoplastic activity apoptosis Article cancer inhibition cell viability cellular distribution concentration response controlled study cytosol down regulation drug cytotoxicity drug effect drug efficacy drug mechanism drug potentiation enzyme activation enzyme activity female G1 phase cell cycle checkpoint gene expression profiling gene expression regulation gene silencing human human cell IC50 in vivo study mouse multiple myeloma multiple myeloma cell line nonhuman protein cleavage protein expression protein phosphorylation RARRES3 gene therapeutic index tumor suppressor gene tumor volume tumor xenograft upregulation
spellingShingle	5 (9 isopropyl 8 methyl 2 morpholino 9h purin 6 yl) 2 pyrimidinamine beta catenin BIM protein bortezomib caspase 3 cyclin D2 cyclin dependent kinase 4 cytochrome c dexamethasone dickkopf 1 protein mammalian target of rapamycin melphalan messenger RNA nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase panobinostat phosphatidylinositol 3 kinase protein Bax protein bcl xl protein kinase B protein S6 survivin Akt signaling animal experiment animal model antineoplastic activity apoptosis Article cancer inhibition cell viability cellular distribution concentration response controlled study cytosol down regulation drug cytotoxicity drug effect drug efficacy drug mechanism drug potentiation enzyme activation enzyme activity female G1 phase cell cycle checkpoint gene expression profiling gene expression regulation gene silencing human human cell IC50 in vivo study mouse multiple myeloma multiple myeloma cell line nonhuman protein cleavage protein expression protein phosphorylation RARRES3 gene therapeutic index tumor suppressor gene tumor volume tumor xenograft upregulation Mustafa, N Ting Lee, J.X Adina Nee, H.F Bi, C Chung, T.-H Hart, S Chng, W.J VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim
description	10.18632/oncotarget.21988
author2	MEDICINE
author_facet	MEDICINE Mustafa, N Ting Lee, J.X Adina Nee, H.F Bi, C Chung, T.-H Hart, S Chng, W.J
format	Article
author	Mustafa, N Ting Lee, J.X Adina Nee, H.F Bi, C Chung, T.-H Hart, S Chng, W.J
author_sort	Mustafa, N
title	VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim
title_short	VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim
title_full	VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim
title_fullStr	VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim
title_full_unstemmed	VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim
title_sort	vs-5584 mediates potent anti-myeloma activity via the upregulation of a class ii tumor suppressor gene, rarres3 and the activation of bim
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/173800
_version_	1821188214461825024

VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim

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