Exocytosis of polyubiquitinated proteins in bortezomib-resistant leukemia cells: A role for MARCKS in acquired resistance to proteasome inhibitors

• Main Authors: Franke, N.E, Kaspers, G.L, Assaraf, Y.G, Meerloo, J, Niewerth, D, Kessler, F.L, Poddighe, P.J, Kole, J, Smeets, S.J, Ylstra, B, Bi, C, Chng, W.J, Horton, T.M, Menezes, R.X, Musters, R.J.P, Zweegman, S, Jansen, G, Cloos, J
• Other Authors: MEDICINE
• Format: Article
• Published: 2020
• Subjects: asparaginase macrogol; bortezomib; cyclophosphamide; DNA; doxorubicin; etoposide; MARCKS protein; messenger RNA; methotrexate; microRNA; prednisone; ubiquitin; vincristine; antineoplastic agent; proteasome inhibitor; acute lymphoblastic leukemia; Article; cancer prognosis; CCRF CEM cell line; controlled study; down regulation; exocytosis; gene expression profiling; gene expression regulation; human; human cell; in vitro study; leukemia cell; MARCKS gene; microarray analysis; oncogene; protein degradation; protein expression; upregulation; comparative genomic hybridization; drug resistance; gene regulatory network; genetics; leukemia; metabolism; mortality; prognosis; tumor cell line; ubiquitination; Antineoplastic Agents; Bortezomib; Cell Line, Tumor; Comparative Genomic Hybridization; Drug Resistance, Neoplasm; Exocytosis; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Gene Regulatory Networks; Humans; Leukemia; MicroRNAs; Myristoylated Alanine-Rich C Kinase Substrate; Prognosis; Proteasome Inhibitors; Ubiquitin; Ubiquitination; Up-Regulation
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174104
• Institution: National University of Singapore

10.18632/oncotarget.11340