Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development

• Main Authors: Wang, L, Khoa Phan, D.D, Zhang, J, Ong, P.-S, Thuya, W.L, Soo, R.A, Wong, A.L.-A, Yong, W.P, Lee, S.C, Ho, P.C.-L, Sethi, G, Goh, B.C
• Other Authors: PHARMACY
• Format: Review
• Published: 2020
• Subjects: nimbolide; resveratrol; romidepsin; limonoid; plant extract; acute toxicity; angiogenesis; antineoplastic activity; antioxidant activity; apoptosis; blood brain barrier; cell cycle G0 phase; cell migration; chemoprophylaxis; cytotoxicity; drug absorption; drug accumulation; drug bioavailability; drug blood level; drug determination; drug efficacy; drug elimination; drug half life; drug isolation; drug metabolism; drug potency; drug potentiation; drug safety; drug structure; flow cytometry; G1 phase cell cycle checkpoint; high performance liquid chromatography; human; IC50; in vitro study; in vivo study; LD50; nonhuman; phase 1 clinical trial (topic); phase 2 clinical trial (topic); Review; animal; Azadirachta indica; cell proliferation; chemistry; drug effects; neoplasm; neovascularization (pathology); phytotherapy; procedures; vascularization; Animals; Apoptosis; Azadirachta; Cell Proliferation; Humans; Limonins; Neoplasms; Neovascularization, Pathologic; Phytotherapy; Plant Extracts
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174111
• Institution: National University of Singapore

10.18632/oncotarget.8316