The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia
10.18632/oncotarget.5436
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sg-nus-scholar.10635-1741132023-09-20T08:41:34Z The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia Ko T.K. Chin H.S. Chuah C.T.H. Huang J.W.J. Ng K.-P. Khaw S.L. Huang D.C.S. Ong S.T. DUKE-NUS MEDICAL SCHOOL 4 [4 (4' chloro 2 biphenylylmethyl) 1 piperazinyl] n [4 [3 dimethylamino 1 (phenylthiomethyl)propylamino] 3 nitrobenzenesulfonyl]benzamide BIM protein imatinib 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide ABT-737 apoptosis regulatory protein BCR ABL protein BCR-ABL1 fusion protein, human BIM protein biphenyl derivative dasatinib imatinib membrane protein nitrophenol oncoprotein piperazine derivative protein kinase inhibitor pyrimidine derivative sulfonamide antineoplastic activity apoptosis Article BCR ABL1 gene BIM gene cancer resistance cell growth chronic myeloid leukemia concentration response controlled study drug mechanism gene gene deletion genetic polymorphism human human cell myeloid leukemia cell line drug effects gene deletion genetic polymorphism genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive tumor cell line Apoptosis Apoptosis Regulatory Proteins Bcl-2-Like Protein 11 Biphenyl Compounds Cell Line, Tumor Dasatinib Fusion Proteins, bcr-abl Gene Deletion Humans Imatinib Mesylate Leukemia, Myelogenous, Chronic, BCR-ABL Positive Membrane Proteins Nitrophenols Piperazines Polymorphism, Genetic Protein Kinase Inhibitors Proto-Oncogene Proteins Pyrimidines Sulfonamides 10.18632/oncotarget.5436 Oncotarget 7 3 2721-2733 2020-09-03T10:32:26Z 2020-09-03T10:32:26Z 2016 Article Ko T.K., Chin H.S., Chuah C.T.H., Huang J.W.J., Ng K.-P., Khaw S.L., Huang D.C.S., Ong S.T. (2016). The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia. Oncotarget 7 (3) : 2721-2733. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.5436 19492553 https://scholarbank.nus.edu.sg/handle/10635/174113 Unpaywall 20200831 |
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4 [4 (4' chloro 2 biphenylylmethyl) 1 piperazinyl] n [4 [3 dimethylamino 1 (phenylthiomethyl)propylamino] 3 nitrobenzenesulfonyl]benzamide BIM protein imatinib 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide ABT-737 apoptosis regulatory protein BCR ABL protein BCR-ABL1 fusion protein, human BIM protein biphenyl derivative dasatinib imatinib membrane protein nitrophenol oncoprotein piperazine derivative protein kinase inhibitor pyrimidine derivative sulfonamide antineoplastic activity apoptosis Article BCR ABL1 gene BIM gene cancer resistance cell growth chronic myeloid leukemia concentration response controlled study drug mechanism gene gene deletion genetic polymorphism human human cell myeloid leukemia cell line drug effects gene deletion genetic polymorphism genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive tumor cell line Apoptosis Apoptosis Regulatory Proteins Bcl-2-Like Protein 11 Biphenyl Compounds Cell Line, Tumor Dasatinib Fusion Proteins, bcr-abl Gene Deletion Humans Imatinib Mesylate Leukemia, Myelogenous, Chronic, BCR-ABL Positive Membrane Proteins Nitrophenols Piperazines Polymorphism, Genetic Protein Kinase Inhibitors Proto-Oncogene Proteins Pyrimidines Sulfonamides |
| spellingShingle |
4 [4 (4' chloro 2 biphenylylmethyl) 1 piperazinyl] n [4 [3 dimethylamino 1 (phenylthiomethyl)propylamino] 3 nitrobenzenesulfonyl]benzamide BIM protein imatinib 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide ABT-737 apoptosis regulatory protein BCR ABL protein BCR-ABL1 fusion protein, human BIM protein biphenyl derivative dasatinib imatinib membrane protein nitrophenol oncoprotein piperazine derivative protein kinase inhibitor pyrimidine derivative sulfonamide antineoplastic activity apoptosis Article BCR ABL1 gene BIM gene cancer resistance cell growth chronic myeloid leukemia concentration response controlled study drug mechanism gene gene deletion genetic polymorphism human human cell myeloid leukemia cell line drug effects gene deletion genetic polymorphism genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive tumor cell line Apoptosis Apoptosis Regulatory Proteins Bcl-2-Like Protein 11 Biphenyl Compounds Cell Line, Tumor Dasatinib Fusion Proteins, bcr-abl Gene Deletion Humans Imatinib Mesylate Leukemia, Myelogenous, Chronic, BCR-ABL Positive Membrane Proteins Nitrophenols Piperazines Polymorphism, Genetic Protein Kinase Inhibitors Proto-Oncogene Proteins Pyrimidines Sulfonamides Ko T.K. Chin H.S. Chuah C.T.H. Huang J.W.J. Ng K.-P. Khaw S.L. Huang D.C.S. Ong S.T. The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia |
| description |
10.18632/oncotarget.5436 |
| author2 |
DUKE-NUS MEDICAL SCHOOL |
| author_facet |
DUKE-NUS MEDICAL SCHOOL Ko T.K. Chin H.S. Chuah C.T.H. Huang J.W.J. Ng K.-P. Khaw S.L. Huang D.C.S. Ong S.T. |
| format |
Article |
| author |
Ko T.K. Chin H.S. Chuah C.T.H. Huang J.W.J. Ng K.-P. Khaw S.L. Huang D.C.S. Ong S.T. |
| author_sort |
Ko T.K. |
| title |
The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia |
| title_short |
The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia |
| title_full |
The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia |
| title_fullStr |
The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia |
| title_full_unstemmed |
The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia |
| title_sort |
bim deletion polymorphism: a paradigm of a permissive interaction between germline and acquired tki resistance factors in chronic myeloid leukemia |
| publishDate |
2020 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/174113 |
| _version_ |
1778169695466160128 |