All that glitters is not gold - Founder effects complicate associations of flu mutations to disease severity

• Main Authors: Lee, R.T, Santos, C.L, Maria De Paiva, T, Cui, L, Sirota, F.L, Eisenhaber, F, Maurer-Stroh, S
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Published: 2020
• Subjects: article; controlled study; disease association; disease severity; epidemiological data; fatality; founder effect; futurology; gene; gene mutation; genome; HA D239G gene; HA D239N gene; HA Q310 H gene; influenza; nonhuman; nucleotide sequence; PB2 K340N gene; phenotype; phylogenetic tree; sample; virus genome; chemical structure; genetics; human; Influenza virus A H1N1; missense mutation; pathogenicity; pathology; phylogeny; prevalence; protein tertiary structure; virology; virulence; hemagglutinin fusogenic peptide, influenza virus; virulence factor; virus hemagglutinin; virus RNA; Founder Effect; Hemagglutinins, Viral; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Models, Molecular; Mutation, Missense; Phylogeny; Prevalence; Protein Structure, Tertiary; RNA, Viral; Virulence; Virulence Factors
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174180
• Institution: National University of Singapore

10.1186/1743-422X-7-297