DR-region of Na + /K + ATPase is a target to treat excitotoxicity and stroke

• Main Authors: Shi, M, Cao, L, Cao, X, Zhu, M, Zhang, X, Wu, Z, Xiong, S, Xie, Z, Yang, Y, Chen, J, Wong, P.T.H, Bian, J.-S
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: adenosine triphosphatase (potassium sodium); calcium; glutamic acid; protein interacting with protein kinase C; AMPA receptor; antibody; glutamate receptor ionotropic, AMPA 2; peptide; sodium calcium exchange protein; animal cell; animal tissue; apoptosis; Article; brain cell culture; brain tissue; calcium cell level; cell membrane; cell viability; cerebrovascular accident; comparative study; confocal microscopy; controlled study; endocytosis; excitotoxicity; immunoprecipitation; infarct volume; internalization; middle cerebral artery occlusion; mouse; nerve cell plasticity; nerve excitability; neuroprotection; nonhuman; priority journal; protein expression; protein phosphorylation; time-lapse microscopy; Western blotting; whole cell patch clamp; animal; brain cortex; chemistry; disease model; genetics; metabolism; nerve cell; pathology; Animals; Antibodies; Cerebral Cortex; Disease Models, Animal; Glutamic Acid; Mice; Neurons; Peptides; Receptors, AMPA; Sodium-Calcium Exchanger; Sodium-Potassium-Exchanging ATPase; Stroke
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174190
• Institution: National University of Singapore

10.1038/s41419-018-1230-5