Formulation, characterization and evaluation of mRNA-loaded dissolvable polymeric microneedles (RNApatch)

• Main Authors: Koh K.J., Liu Y., Lim S.H., Loh X.J., Kang L., Lim C.Y., Phua K.K.L.
• Other Authors: INDUSTRY LIAISON OFFICE
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: messenger RNA; polymer; povidone; animal; C57BL mouse; chemistry; devices; drug delivery system; female; genetics; human; immunotherapy; microinjection; needle; pharmaceutics; procedures; solubility; subcutaneous drug administration; transdermal patch; tumor cell line; Animals; Cell Line, Tumor; Drug Delivery Systems; Female; Humans; Immunotherapy; Injections, Subcutaneous; Mice, Inbred C57BL; Microinjections; Needles; Polymers; Povidone; RNA, Messenger; Solubility; Technology, Pharmaceutical; Transdermal Patch
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174212
• Institution: National University of Singapore

10.1038/s41598-018-30290-3