Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens

• Main Authors: Rassidakis, G.Z, Herold, N, Myrberg, I.H, Tsesmetzis, N, Rudd, S.G, Henter, J.-I, Schaller, T, Ng, S.-B, Chng, W.J, Yan, B, Ng, C.H, Ravandi, F, Andreeff, M, Kantarjian, H.M, Medeiros, L.J, Xagoraris, I, Khoury, J.D
• Other Authors: PATHOLOGY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: cladribine; clofarabine; cytarabine; deoxynucleoside triphosphate triphosphohydrolase SAMHD1; DNA methyltransferase 3A; fludarabine; gemtuzumab ozogamicin; sorafenib; vorinostat; antineoplastic agent; SAMHD1 protein, human; tumor marker; acute myeloid leukemia; adult; aged; allogeneic stem cell transplantation; Article; blood; bone marrow; cancer patient; clinical outcome; cohort analysis; consolidation chemotherapy; controlled study; de novo acute myeloid leukemia; drug megadose; event free survival; female; follow up; high risk population; human; immunohistochemistry; induction chemotherapy; leukocyte count; low drug dose; major clinical study; male; megakaryocyte; protein expression; tissue microarray; very elderly; adolescent; gene expression regulation; genetics; Kaplan Meier method; metabolism; middle aged; mortality; multimodality cancer therapy; pathology; prognosis; proportional hazards model; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Marrow; Combined Modality Therapy; Consolidation Chemotherapy; Cytarabine; Female; Gene Expression Regulation, Leukemic; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Male; Middle Aged; Prognosis; Proportional Hazards Models; SAM Domain and HD Domain-Containing Protein 1; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174354
• Institution: National University of Singapore

10.1038/s41408-018-0134-z