Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infant

• Main Authors: Krishnan, M.L, Van Steenwinckel, J, Schang, A.-L, Yan, J, Arnadottir, J, Le Charpentier, T, Csaba, Z, Dournaud, P, Cipriani, S, Auvynet, C, Titomanlio, L, Pansiot, J, Ball, G, Boardman, J.P, Walley, A.J, Saxena, A, Mirza, G, Fleiss, B, Edwards, A.D, Petretto, E, Gressens, P
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: interleukin 1beta; postsynaptic density protein 95; STAT3 protein; transcriptome; disks large homolog 4; DLG4 protein, human; brain; cells and cell components; developmental biology; gene; gene expression; genetic variation; genomics; neonate; protein; adult; animal cell; animal experiment; animal model; animal tissue; Article; blood brain barrier; brain disease; cell function; controlled study; gene cluster; gene structure; genetic analysis; genetic variability; human; human tissue; infant; microglia; mouse; mouse model; neuroimaging; nonhuman; prematurity; protein protein interaction; protein synthesis; transcriptomics; white matter; animal; drug effects; gene expression regulation; gene regulatory network; genetics; growth, development and aging; inflammation; metabolism; neuropsychiatry; newborn; nuclear magnetic resonance imaging; pathology; quantitative trait locus; Animals; Brain; Disks Large Homolog 4 Protein; Gene Expression Regulation; Gene Regulatory Networks; Genomics; Humans; Infant, Newborn; Infant, Premature; Inflammation; Interleukin-1beta; Magnetic Resonance Imaging; Mice; Microglia; Neuropsychiatry; Protein Interaction Maps; Quantitative Trait Loci; STAT3 Transcription Factor; Transcriptome; White Matter
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174399
• Institution: National University of Singapore

10.1038/s41467-017-00422-w