The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants

• Main Authors: Yuan, J, Ng, W.H, Lam, P.Y.P, Wang, Y, Xia, H, Yap, J, Guan, S.P, Lee, A.S.G, Wang, M, Baccarini, M, Hu, J
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: A Raf kinase; B Raf kinase; dimer; glutamic acid; isoenzyme; mitogen activated protein kinase; mitogen activated protein kinase kinase; mutant protein; Raf protein; valine; allosterism; animal experiment; animal model; animal tissue; Article; binding affinity; cancer therapy; catalysis; controlled study; dimerization; enzyme activation; enzyme activity; enzyme analysis; enzyme phosphorylation; female; gene mutation; human; human cell; molecular biology; mouse; nonhuman; priority journal; protein family; protein motif; animal; enzymology; genetics; knockout mouse; MAPK signaling; metabolism; mutation; neoplasm; pathology; protein multimerization; tumor cell line; Animals; Catalysis; Cell Line, Tumor; MAP Kinase Signaling System; Mice; Mice, Knockout; Mutation; Neoplasms; Protein Multimerization; raf Kinases
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175101
• Institution: National University of Singapore

10.1038/s41388-018-0365-2