Towards selective mycobacterial ClpP1P2 inhibitors with reduced activity against the human proteasome

10.1128/AAC.02307-16

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Main Authors:	Moreira, W, Santhanakrishnan, S, Ngan, G.J.Y, Low, C.B, Sangthongpitag, K, Poulsen, A, Dymock, B.W, Dick, T
Other Authors:	MICROBIOLOGY AND IMMUNOLOGY
Format:	Article
Published:	American Society for Microbiology 2020
Subjects:	3 phenyl 1 [[2 (pyrazine 2 carboxamido) 3 (pyridin 2 yl)propanimido]propyl]boronic acid boronic acid derivative bortezomib cytochrome P450 proteasome inhibitor proteinase inhibitor unclassified drug antiinfective agent bacterial protein ClpP2 protein, bacteria endopeptidase Clp serine proteinase animal experiment animal model antibacterial activity Article bacterial growth bactericidal activity controlled study drug solubility enzyme inhibition growth inhibition human human cell mouse Mycobacterium tuberculosis nonhuman plasma protein binding priority journal animal antagonists and inhibitors drug design drug effects genetics lung tuberculosis microbial sensitivity test microbiology molecular model Mycobacterium smegmatis Animals Anti-Bacterial Agents Bacterial Proteins Bortezomib Drug Design Endopeptidase Clp Mice Microbial Sensitivity Tests Models, Molecular Proteasome Inhibitors Serine Endopeptidases Tuberculosis, Pulmonary
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/175227
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1752272024-04-05T09:03:13Z Towards selective mycobacterial ClpP1P2 inhibitors with reduced activity against the human proteasome Moreira, W Santhanakrishnan, S Ngan, G.J.Y Low, C.B Sangthongpitag, K Poulsen, A Dymock, B.W Dick, T MICROBIOLOGY AND IMMUNOLOGY PHARMACY DEPT OF CHEMISTRY 3 phenyl 1 [[2 (pyrazine 2 carboxamido) 3 (pyridin 2 yl)propanimido]propyl]boronic acid boronic acid derivative bortezomib cytochrome P450 proteasome inhibitor proteinase inhibitor unclassified drug antiinfective agent bacterial protein bortezomib ClpP2 protein, bacteria endopeptidase Clp proteasome inhibitor serine proteinase animal experiment animal model antibacterial activity Article bacterial growth bactericidal activity controlled study drug solubility enzyme inhibition growth inhibition human human cell mouse Mycobacterium tuberculosis nonhuman plasma protein binding priority journal animal antagonists and inhibitors drug design drug effects genetics lung tuberculosis microbial sensitivity test microbiology molecular model Mycobacterium smegmatis Animals Anti-Bacterial Agents Bacterial Proteins Bortezomib Drug Design Endopeptidase Clp Mice Microbial Sensitivity Tests Models, Molecular Mycobacterium smegmatis Mycobacterium tuberculosis Proteasome Inhibitors Serine Endopeptidases Tuberculosis, Pulmonary 10.1128/AAC.02307-16 Antimicrobial Agents and Chemotherapy 61 5 e02307 2020-09-09T06:24:41Z 2020-09-09T06:24:41Z 2017 Article Moreira, W, Santhanakrishnan, S, Ngan, G.J.Y, Low, C.B, Sangthongpitag, K, Poulsen, A, Dymock, B.W, Dick, T (2017). Towards selective mycobacterial ClpP1P2 inhibitors with reduced activity against the human proteasome. Antimicrobial Agents and Chemotherapy 61 (5) : e02307. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.02307-16 0066-4804 https://scholarbank.nus.edu.sg/handle/10635/175227 American Society for Microbiology Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	3 phenyl 1 [[2 (pyrazine 2 carboxamido) 3 (pyridin 2 yl)propanimido]propyl]boronic acid boronic acid derivative bortezomib cytochrome P450 proteasome inhibitor proteinase inhibitor unclassified drug antiinfective agent bacterial protein bortezomib ClpP2 protein, bacteria endopeptidase Clp proteasome inhibitor serine proteinase animal experiment animal model antibacterial activity Article bacterial growth bactericidal activity controlled study drug solubility enzyme inhibition growth inhibition human human cell mouse Mycobacterium tuberculosis nonhuman plasma protein binding priority journal animal antagonists and inhibitors drug design drug effects genetics lung tuberculosis microbial sensitivity test microbiology molecular model Mycobacterium smegmatis Animals Anti-Bacterial Agents Bacterial Proteins Bortezomib Drug Design Endopeptidase Clp Mice Microbial Sensitivity Tests Models, Molecular Mycobacterium smegmatis Mycobacterium tuberculosis Proteasome Inhibitors Serine Endopeptidases Tuberculosis, Pulmonary
spellingShingle	3 phenyl 1 [[2 (pyrazine 2 carboxamido) 3 (pyridin 2 yl)propanimido]propyl]boronic acid boronic acid derivative bortezomib cytochrome P450 proteasome inhibitor proteinase inhibitor unclassified drug antiinfective agent bacterial protein bortezomib ClpP2 protein, bacteria endopeptidase Clp proteasome inhibitor serine proteinase animal experiment animal model antibacterial activity Article bacterial growth bactericidal activity controlled study drug solubility enzyme inhibition growth inhibition human human cell mouse Mycobacterium tuberculosis nonhuman plasma protein binding priority journal animal antagonists and inhibitors drug design drug effects genetics lung tuberculosis microbial sensitivity test microbiology molecular model Mycobacterium smegmatis Animals Anti-Bacterial Agents Bacterial Proteins Bortezomib Drug Design Endopeptidase Clp Mice Microbial Sensitivity Tests Models, Molecular Mycobacterium smegmatis Mycobacterium tuberculosis Proteasome Inhibitors Serine Endopeptidases Tuberculosis, Pulmonary Moreira, W Santhanakrishnan, S Ngan, G.J.Y Low, C.B Sangthongpitag, K Poulsen, A Dymock, B.W Dick, T Towards selective mycobacterial ClpP1P2 inhibitors with reduced activity against the human proteasome
description	10.1128/AAC.02307-16
author2	MICROBIOLOGY AND IMMUNOLOGY
author_facet	MICROBIOLOGY AND IMMUNOLOGY Moreira, W Santhanakrishnan, S Ngan, G.J.Y Low, C.B Sangthongpitag, K Poulsen, A Dymock, B.W Dick, T
format	Article
author	Moreira, W Santhanakrishnan, S Ngan, G.J.Y Low, C.B Sangthongpitag, K Poulsen, A Dymock, B.W Dick, T
author_sort	Moreira, W
title	Towards selective mycobacterial ClpP1P2 inhibitors with reduced activity against the human proteasome
title_short	Towards selective mycobacterial ClpP1P2 inhibitors with reduced activity against the human proteasome
title_full	Towards selective mycobacterial ClpP1P2 inhibitors with reduced activity against the human proteasome
title_fullStr	Towards selective mycobacterial ClpP1P2 inhibitors with reduced activity against the human proteasome
title_full_unstemmed	Towards selective mycobacterial ClpP1P2 inhibitors with reduced activity against the human proteasome
title_sort	towards selective mycobacterial clpp1p2 inhibitors with reduced activity against the human proteasome
publisher	American Society for Microbiology
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/175227
_version_	1800914351375253504

Towards selective mycobacterial ClpP1P2 inhibitors with reduced activity against the human proteasome

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