Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease

• Main Authors: Ooi, J, Hayden, M.R, Pouladi, M.A
• Other Authors: DEAN'S OFFICE (MEDICINE)
• Format: Article
• Published: Humana Press Inc. 2020
• Subjects: amine oxidase (flavin containing) isoenzyme A; amine oxidase (flavin containing) isoenzyme B; clorgyline; huntingtin; phenelzine; selegiline; amine oxidase (flavin containing); dopamine; HTT protein, human; nerve protein; serotonin transporter; Slc6a4 protein, mouse; adult; aged; animal cell; Article; CAG repeat; cell stress; cell viability; child; clinical article; controlled study; corpus striatum; drug effect; enzyme activity; enzyme inhibition; epigenetics; female; human; human cell; Huntington chorea; male; middle aged; mouse; mutant; nerve cell differentiation; nerve cell necrosis; neural stem cell; neuroprotection; nonhuman; oxidative stress; pluripotent stem cell; preschool child; protein expression; skin fibroblast; young adult; animal; cell culture; cell death; disease model; metabolism; nerve cell; physiology; Animals; Cell Death; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dopamine; Humans; Huntingtin Protein; Huntington Disease; Mice; Monoamine Oxidase; Nerve Tissue Proteins; Neurons; Oxidative Stress; Serotonin Plasma Membrane Transport Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175275
• Institution: National University of Singapore

10.1007/s12035-014-8974-4