Intra-patient and inter-patient comparisons of DNA damage response biomarkers in Nasopharynx Cancer (NPC): Analysis of NCC0901 randomised controlled trial of induction chemotherapy in locally advanced NPC

• Main Authors: Chua K.L.M., Yeo E.L.L., Shihabudeen W.A., Tan S.H., Shwe T.T., Ong E.H.W., Lam P.Y.P., Soo K.C., Soong Y.L., Fong K.W., Tan T.W.K., Wee J.T.S., Chua M.L.K.
• Other Authors: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
• Format: Article
• Published: 2020
• Subjects: biological marker; carboplatin; gemcitabine; histone H2AX; paclitaxel; antineoplastic agent; histone; adult; advanced cancer; age; apoptosis; Article; cancer chemotherapy; cancer radiotherapy; case control study; CD4+ T lymphocyte; CD8+ T lymphocyte; cell assay; cohort analysis; comparative study; controlled study; DNA damage response; DNA repair; ex vivo study; exploratory research; female; human; human cell; induction chemotherapy; lymphocyte; major clinical study; male; middle aged; nasopharynx cancer; phase 2 clinical trial (topic); phase 3 clinical trial (topic); radiation dose; radiation injury; randomized controlled trial (topic); retrospective study; xerostomia; aged; cancer staging; clinical trial; DNA damage; drug effect; genetics; ionizing radiation; metabolism; nasopharynx tumor; pathology; phase 2 clinical trial; phase 3 clinical trial; radiation response; young adult; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; DNA Damage; DNA Repair; Female; Histones; Humans; Induction Chemotherapy; Male; Middle Aged; Nasopharyngeal Neoplasms; Neoplasm Staging; Radiation, Ionizing; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175356
• Institution: National University of Singapore

10.1186/s12885-018-5005-2