A phase I/Ib study of OTSGC-A24 combined peptide vaccine in advanced gastric cancer

• Main Authors: Sundar, R, Rha, S.Y, Yamaue, H, Katsuda, M, Kono, K, Kim, H.S, Kim, C, Mimura, K, Kua, L.-F, Yong, W.P
• Other Authors: LIFE SCIENCES INSTITUTE
• Format: Article
• Published: 2020
• Subjects: alkaline phosphatase; aspartate aminotransferase; cancer vaccine; HLA A antigen; otgsc a24; otsgc a24; peptide vaccine; unclassified drug; biological marker; HLA A24 antigen; subunit vaccine; abdominal pain; adult; advanced cancer; adverse outcome; aged; alkaline phosphatase blood level; anemia; antineoplastic activity; Article; aspartate aminotransferase blood level; cancer pain; clinical article; cohort analysis; constipation; controlled study; coughing; cytotoxic T lymphocyte; decreased appetite; diarrhea; dizziness; drug effect; drug efficacy; drug response; drug safety; drug tolerability; dyspepsia; dysphagia; dyspnea; enzyme linked immunospot assay; ex vivo study; female; fever; gastrointestinal reflux; haplotype; human; hyperbilirubinemia; hyperkalemia; hypokalemia; hyponatremia; immune response; injection site erythema; injection site ulcer; loss of appetite; lung infection; malaise; male; myalgia; nausea; open study; overall survival; peripheral edema; phase 1 clinical trial; progression free survival; pruritus; stomach cancer; stomach tumor; survival rate; treatment outcome; upper respiratory tract infection; vaccination; vomiting; cancer staging; clinical trial; cytotoxicity; genetics; immunology; metabolism; metastasis; middle aged; mortality; multimodality cancer therapy; pathology; Adult; Aged; Biomarkers; Cancer Vaccines; Combined Modality Therapy; Cytotoxicity, Immunologic; Female; Haplotypes; HLA-A24 Antigen; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Stomach Neoplasms; T-Lymphocytes, Cytotoxic; Vaccines, Subunit
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175397
• Institution: National University of Singapore

10.1186/s12885-018-4234-8