In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate

• Main Authors: Cravo, P, Machado, R.B, Leite, J.A, Leda, T, Suwanarusk, R, Bittencourt, N, Albrecht, L, Judice, C, Lopes, S.C.P, Lacerda, M.V.G, Ferreira, M.U, Soares, I.S, Goh, Y.S, Bargieri, D.Y, Nosten, F, Russell, B, Rénia, L, Costa, F.T.M
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: 2020
• Subjects: epitope; major histocompatibility antigen class 1; major histocompatibility antigen class 2; malaria vaccine; merozoite adhesive erythrocytic binding protein antigen; unclassified drug; parasite antigen; protozoal protein; Amazonas (Brazil); amino acid sequence; animal experiment; animal model; Article; B lymphocyte; cell invasion; clinical article; computer model; controlled study; dose response; drug dose comparison; epitope mapping; erythrocyte; ex vivo study; human; immunogenicity; malaria falciparum; molecular cloning; mouse; nonhuman; parasite isolation; Plasmodium falciparum; Plasmodium vivax; Plasmodium vivax malaria; Plasmodium yoelii; protein domain; sequence alignment; Thailand; animal; biology; C57BL mouse; conserved sequence; genetics; immunology; isolation and purification; Animals; Antigens, Protozoan; Computational Biology; Conserved Sequence; Epitope Mapping; Epitopes; Humans; Malaria Vaccines; Malaria, Falciparum; Malaria, Vivax; Mice, Inbred C57BL; Protozoan Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175407
• Institution: National University of Singapore

10.1186/s12936-017-2144-x