AZD6244 and doxorubicin induce growth suppression and apoptosis in mouse models of hepatocellular carcinoma

AZD6244 and doxorubicin induce growth suppression and apoptosis in mouse models of hepatocellular carcinoma

10.1158/1535-7163.MCT-07-0162

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Bibliographic Details
Main Authors:	Huynh, H, Chow, P.K.H, Soo, K.-C
Other Authors:	MEDICINE
Format:	Article
Published:	2020
Subjects:	azd 6244 cell cycle protein cell cycle protein 2 cyclin B1 cyclin D1 cyclin dependent kinase 2 cyclin dependent kinase 4 doxorubicin mitogen activated protein kinase inhibitor Myc protein unclassified drug animal experiment animal model animal tissue apoptosis article cancer cell culture cancer combination chemotherapy cancer growth cancer inhibition cell cycle cell proliferation clinical study combination chemotherapy concentration response controlled study down regulation drug potentiation gene inactivation liver cell carcinoma male mouse nonhuman oncogene c myc priority journal tumor xenograft Animals Antibiotics, Antineoplastic Apoptosis Benzimidazoles Blotting, Western Carcinoma, Hepatocellular Cell Cycle Cell Line, Tumor Cell Proliferation Crk-Associated Substrate Protein Cyclins Doxorubicin Drug Therapy, Combination Fluorescent Antibody Technique Humans In Situ Nick-End Labeling Liver Neoplasms Male Mice Mice, SCID Survival Rate Transplantation, Heterologous
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/177992
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Institution:	National University of Singapore

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Summary:	10.1158/1535-7163.MCT-07-0162