Novel self-epitopes derived from aggrecan, fibrillin, and matrix metalloproteinase-3 drive distinct autoreactive T-cell responses in juvenile idiopathic arthritis and in health

• Main Authors: Kamphuis, S, Hrafnkelsdóttir, K, Klein, M.R, de Jager, W, Haverkamp, M.H, van Bilsen, J.H.M, Albani, S, Kuis, W, Wauben, M.H.M, Prakken, B.J
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: aggrecan; autoantigen; cytokine; epitope; fibrillin; gamma interferon; interleukin 10; interleukin 17; methotrexate; salazosulfapyridine; stromelysin; actin binding protein; adolescent; adult; article; cell line; child; clinical article; controlled study; cytokine production; disease duration; female; genotype; human; human cell; immune response; juvenile rheumatoid arthritis; lymphocyte proliferation; major histocompatibility complex; male; pathogenesis; peripheral blood mononuclear cell; T lymphocyte; autoimmunity; biosynthesis; flow cytometry; immunology; onset age; preschool child; Age of Onset; Aggrecans; Arthritis, Juvenile; Autoantigens; Autoimmunity; Child; Child, Preschool; Cytokines; Epitopes, T-Lymphocyte; Female; Flow Cytometry; Humans; Male; Matrix Metalloproteinase 3; Microfilament Proteins; T-Lymphocytes
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178011
• Institution: National University of Singapore

10.1186/ar2088