Combined influence of B-cell receptor rearrangement and somatic hypermutation on B-cell class-switch fate in health and in chronic lymphocytic leukemia

• Main Authors: Petrova, V.N, Muir, L, McKay, P.F, Vassiliou, G.S, Smith, K.G.C, Lyons, P.A, Russell, C.A, Anderson, C.A, Kellam, P, Bashford-Rogers, R.J.M
• Other Authors: MEDICINE
• Format: Article
• Published: 2020
• Subjects: B lymphocyte receptor; immunoglobulin class; lymphocyte antigen receptor; Article; B lymphocyte; chronic lymphatic leukemia; clinical article; controlled study; fluorescence activated cell sorting; gene frequency; gene library; gene sequence; genetic variability; human; human cell; immune response; memory cell; molecular genetics; peripheral blood mononuclear cell; phylogeny; somatic hypermutation; genetics; immunoglobulin class switching; immunoglobulin structure; immunoglobulin variable region; immunology; metabolism; mononuclear cell; multigene family; pathology; B-Lymphocytes; Gene Rearrangement, B-Lymphocyte; Humans; Immunoglobulin Class Switching; Immunoglobulin Isotypes; Immunoglobulin Joining Region; Immunoglobulin Variable Region; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Multigene Family; Receptors, Antigen, B-Cell; Somatic Hypermutation, Immunoglobulin
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178070
• Institution: National University of Singapore

10.3389/fimmu.2018.01784