Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage

• Main Authors: Pursani, V, Bhartiya, D, Tanavde, V, Bashir, M, Sampath, P
• Other Authors: DEPT OF BIOCHEMISTRY
• Format: Article
• Published: 2020
• Subjects: histone methyltransferase; histone methyltransferase DOT1L; homeobox protein Nkx-2.5; octamer transcription factor 4; small interfering RNA; transcription factor NANOG; unclassified drug; basic helix loop helix transcription factor; calcium binding protein; DOT1L protein, human; helix-loop-helix protein, eHAND; membrane protein; methyltransferase; muscle protein; MYOF protein, human; NFE2L2 protein, human; NKX2-5 protein, human; transcription factor Nrf2; Article; cardiac cell line; cardiac stem cell; cell activity; cell differentiation; chromatin immunoprecipitation; controlled study; embryo; enzyme localization; gene; gene activation; gene expression regulation; gene knockdown; gene sequence; gene targeting; HAND1 gene; heart development; HES3 cell; human; human cell; human embryonic stem cell; immunofluorescence; in vitro study; KIND1 cell; marker gene; MYOF gene; NANOG gene; NKX25 gene; NR2F2 gene; pluripotent stem cell; POU5F1 gene; priority journal; transcription initiation site; transcription regulation; cardiac muscle cell; cell culture; cell line; cell lineage; cytology; genetics; metabolism; Basic Helix-Loop-Helix Transcription Factors; Calcium-Binding Proteins; Cell Differentiation; Cell Line; Cell Lineage; Cells, Cultured; Homeobox Protein Nkx-2.5; Human Embryonic Stem Cells; Humans; Membrane Proteins; Methyltransferases; Muscle Proteins; Myocytes, Cardiac; NF-E2-Related Factor 2
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178092
• Institution: National University of Singapore

10.1186/s13287-018-0810-8