Candida albicans gains azole resistance by altering sphingolipid composition

• Main Authors: Gao, J, Wang, H, Li, Z, Wong, A.H.-H, Wang, Y.-Z, Guo, Y, Lin, X, Zeng, G, Wang, Y, Wang, J
• Other Authors: BIOCHEMISTRY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: double stranded DNA; fluconazole; fungal DNA; genomic DNA; piggybac transposase; sphingolipid; transposase; unclassified drug; very long chain fatty acid; pyrrole derivative; sterol; chemical composition; drug resistance; fatty acid; fungus; genetic analysis; genome; lipid; mass spectrometry; mutagenicity; mutation; pesticide resistance; antifungal resistance; Article; Candida albicans; controlled study; DNA content; fatty acid synthesis; fungal genome; fungal strain; genetic screening; lipid composition; lipogenesis; mutagenesis; nonhuman; nuclear localization signal; transposon; upregulation; drug effect; fungal gene; genetics; haploidy; metabolism; nucleotide sequence; physiology; Azoles; Base Sequence; DNA Transposable Elements; Drug Resistance, Fungal; Genes, Fungal; Genetic Testing; Haploidy; Mutagenesis; Mutation; Sphingolipids; Sterols
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178388

10.1038/s41467-018-06944-1