MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation

10.1038/s41467-018-03563-8

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Main Authors:	Zhou, P, Ding, X, Wan, X, Liu, L, Yuan, X, Zhang, W, Hui, X, Meng, G, Xiao, H, Li, B, Zhong, J, Hou, F, Deng, L, Zhang, Y
Other Authors:	BIOCHEMISTRY
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	protein protein MLL5 protein STUB1 retinoic acid inducible protein I ubiquitin protein ligase E3 unclassified drug antivirus agent Ddx58 protein, mouse DNA binding protein histone lysine methyltransferase MLL5 protein, human MLL5 protein, mouse proteasome STUB1 protein, human Stub1 protein, mouse ubiquitin protein ligase cytoplasm degradation gene gene expression genetic analysis immune response rodent animal cell animal experiment animal model animal tissue antiviral activity Article controlled study embryo female human human cell in vitro study in vivo study innate immunity mouse nonhuman protein function Sendai virus ubiquitination Vesiculovirus virus infection virus load virus replication animal C57BL mouse CRISPR Cas system DNA damage HEK293 cell line immunology male metabolism rhabdovirus infection RNA interference signal transduction Vesicular stomatitis Indiana virus Mus Vesicular stomatitis virus Animals Antiviral Agents CRISPR-Cas Systems Cytoplasm DEAD Box Protein 58 DNA Damage DNA-Binding Proteins Female HEK293 Cells Histone-Lysine N-Methyltransferase Humans Immunity, Innate Male Mice Mice, Inbred C57BL Proteasome Endopeptidase Complex Rhabdoviridae Infections RNA Interference Signal Transduction Ubiquitin-Protein Ligases Ubiquitination Virus Replication
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/178419
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1784192024-11-09T20:45:14Z MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation Zhou, P Ding, X Wan, X Liu, L Yuan, X Zhang, W Hui, X Meng, G Xiao, H Li, B Zhong, J Hou, F Deng, L Zhang, Y BIOCHEMISTRY protein protein MLL5 protein STUB1 retinoic acid inducible protein I ubiquitin protein ligase E3 unclassified drug antivirus agent Ddx58 protein, mouse DNA binding protein histone lysine methyltransferase MLL5 protein, human MLL5 protein, mouse proteasome retinoic acid inducible protein I STUB1 protein, human Stub1 protein, mouse ubiquitin protein ligase cytoplasm degradation gene gene expression genetic analysis immune response protein rodent animal cell animal experiment animal model animal tissue antiviral activity Article controlled study cytoplasm embryo female human human cell in vitro study in vivo study innate immunity mouse nonhuman protein function Sendai virus ubiquitination Vesiculovirus virus infection virus load virus replication animal C57BL mouse CRISPR Cas system DNA damage HEK293 cell line immunology male metabolism rhabdovirus infection RNA interference signal transduction Vesicular stomatitis Indiana virus Mus Vesicular stomatitis virus Animals Antiviral Agents CRISPR-Cas Systems Cytoplasm DEAD Box Protein 58 DNA Damage DNA-Binding Proteins Female HEK293 Cells Histone-Lysine N-Methyltransferase Humans Immunity, Innate Male Mice Mice, Inbred C57BL Proteasome Endopeptidase Complex Rhabdoviridae Infections RNA Interference Signal Transduction Ubiquitin-Protein Ligases Ubiquitination Vesicular stomatitis Indiana virus Virus Replication 10.1038/s41467-018-03563-8 Nature Communications 9 1 1243 2020-10-20T09:52:22Z 2020-10-20T09:52:22Z 2018 Article Zhou, P, Ding, X, Wan, X, Liu, L, Yuan, X, Zhang, W, Hui, X, Meng, G, Xiao, H, Li, B, Zhong, J, Hou, F, Deng, L, Zhang, Y (2018). MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation. Nature Communications 9 (1) : 1243. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-03563-8 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/178419 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	protein protein MLL5 protein STUB1 retinoic acid inducible protein I ubiquitin protein ligase E3 unclassified drug antivirus agent Ddx58 protein, mouse DNA binding protein histone lysine methyltransferase MLL5 protein, human MLL5 protein, mouse proteasome retinoic acid inducible protein I STUB1 protein, human Stub1 protein, mouse ubiquitin protein ligase cytoplasm degradation gene gene expression genetic analysis immune response protein rodent animal cell animal experiment animal model animal tissue antiviral activity Article controlled study cytoplasm embryo female human human cell in vitro study in vivo study innate immunity mouse nonhuman protein function Sendai virus ubiquitination Vesiculovirus virus infection virus load virus replication animal C57BL mouse CRISPR Cas system DNA damage HEK293 cell line immunology male metabolism rhabdovirus infection RNA interference signal transduction Vesicular stomatitis Indiana virus Mus Vesicular stomatitis virus Animals Antiviral Agents CRISPR-Cas Systems Cytoplasm DEAD Box Protein 58 DNA Damage DNA-Binding Proteins Female HEK293 Cells Histone-Lysine N-Methyltransferase Humans Immunity, Innate Male Mice Mice, Inbred C57BL Proteasome Endopeptidase Complex Rhabdoviridae Infections RNA Interference Signal Transduction Ubiquitin-Protein Ligases Ubiquitination Vesicular stomatitis Indiana virus Virus Replication
spellingShingle	protein protein MLL5 protein STUB1 retinoic acid inducible protein I ubiquitin protein ligase E3 unclassified drug antivirus agent Ddx58 protein, mouse DNA binding protein histone lysine methyltransferase MLL5 protein, human MLL5 protein, mouse proteasome retinoic acid inducible protein I STUB1 protein, human Stub1 protein, mouse ubiquitin protein ligase cytoplasm degradation gene gene expression genetic analysis immune response protein rodent animal cell animal experiment animal model animal tissue antiviral activity Article controlled study cytoplasm embryo female human human cell in vitro study in vivo study innate immunity mouse nonhuman protein function Sendai virus ubiquitination Vesiculovirus virus infection virus load virus replication animal C57BL mouse CRISPR Cas system DNA damage HEK293 cell line immunology male metabolism rhabdovirus infection RNA interference signal transduction Vesicular stomatitis Indiana virus Mus Vesicular stomatitis virus Animals Antiviral Agents CRISPR-Cas Systems Cytoplasm DEAD Box Protein 58 DNA Damage DNA-Binding Proteins Female HEK293 Cells Histone-Lysine N-Methyltransferase Humans Immunity, Innate Male Mice Mice, Inbred C57BL Proteasome Endopeptidase Complex Rhabdoviridae Infections RNA Interference Signal Transduction Ubiquitin-Protein Ligases Ubiquitination Vesicular stomatitis Indiana virus Virus Replication Zhou, P Ding, X Wan, X Liu, L Yuan, X Zhang, W Hui, X Meng, G Xiao, H Li, B Zhong, J Hou, F Deng, L Zhang, Y MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation
description	10.1038/s41467-018-03563-8
author2	BIOCHEMISTRY
author_facet	BIOCHEMISTRY Zhou, P Ding, X Wan, X Liu, L Yuan, X Zhang, W Hui, X Meng, G Xiao, H Li, B Zhong, J Hou, F Deng, L Zhang, Y
format	Article
author	Zhou, P Ding, X Wan, X Liu, L Yuan, X Zhang, W Hui, X Meng, G Xiao, H Li, B Zhong, J Hou, F Deng, L Zhang, Y
author_sort	Zhou, P
title	MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation
title_short	MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation
title_full	MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation
title_fullStr	MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation
title_full_unstemmed	MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation
title_sort	mll5 suppresses antiviral innate immune response by facilitating stub1-mediated rig-i degradation
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/178419
_version_	1821199903872778240

MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation

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