Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis

10.1038/s41467-017-02086-y

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Main Authors:	Zhong, W, Cui, L, Goh, B.C, Cai, Q, Ho, P, Chionh, Y.H, Yuan, M, Sahili, A.E, Fothergill-Gilmore, L.A, Walkinshaw, M.D, Lescar, J, Dedon, P.C
其他作者:	DUKE-NUS MEDICAL SCHOOL
格式:	Article
出版:	Nature Publishing Group 2020
主題:	adenosine phosphate glucose 6 phosphate pyruvate kinase glucose energy enzyme activity metabolism metabolite network analysis nutrient sugar tuberculosis allosteric site allosterism amino acid sequence Article carboxy terminal sequence comparative study conformational transition controlled study energy metabolism enzyme activation enzyme kinetics enzyme stability enzyme structure gene expression system glucose metabolism metabolic regulation molecular dynamics Mycobacterium bovis BCG nonhuman protein protein interaction chemistry enzyme assay kinetics metabolome metabolomics molecular docking Mycobacterium bovis Mycobacterium tuberculosis protein domain X ray crystallography Bacteria (microorganisms) Adenosine Monophosphate Allosteric Regulation Crystallography, X-Ray Enzyme Assays Glucose Glucose-6-Phosphate Kinetics Metabolome Metabolomics Molecular Docking Simulation Protein Domains Pyruvate Kinase
在線閱讀:	https://scholarbank.nus.edu.sg/handle/10635/178553
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機構:	National University of Singapore

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spelling	sg-nus-scholar.10635-1785532024-11-14T04:04:53Z Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis Zhong, W Cui, L Goh, B.C Cai, Q Ho, P Chionh, Y.H Yuan, M Sahili, A.E Fothergill-Gilmore, L.A Walkinshaw, M.D Lescar, J Dedon, P.C DUKE-NUS MEDICAL SCHOOL adenosine phosphate glucose 6 phosphate pyruvate kinase adenosine phosphate glucose glucose 6 phosphate pyruvate kinase energy enzyme activity metabolism metabolite network analysis nutrient sugar tuberculosis allosteric site allosterism amino acid sequence Article carboxy terminal sequence comparative study conformational transition controlled study energy metabolism enzyme activation enzyme activity enzyme kinetics enzyme stability enzyme structure gene expression system glucose metabolism metabolic regulation molecular dynamics Mycobacterium bovis BCG nonhuman nutrient protein protein interaction allosterism chemistry enzyme assay kinetics metabolism metabolome metabolomics molecular docking Mycobacterium bovis Mycobacterium tuberculosis protein domain X ray crystallography Bacteria (microorganisms) Mycobacterium bovis BCG Mycobacterium tuberculosis Adenosine Monophosphate Allosteric Regulation Crystallography, X-Ray Enzyme Assays Glucose Glucose-6-Phosphate Kinetics Metabolome Metabolomics Molecular Docking Simulation Mycobacterium bovis Mycobacterium tuberculosis Protein Domains Pyruvate Kinase 10.1038/s41467-017-02086-y Nature Communications 8 1 1986 2020-10-20T10:17:21Z 2020-10-20T10:17:21Z 2017 Article Zhong, W, Cui, L, Goh, B.C, Cai, Q, Ho, P, Chionh, Y.H, Yuan, M, Sahili, A.E, Fothergill-Gilmore, L.A, Walkinshaw, M.D, Lescar, J, Dedon, P.C (2017). Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis. Nature Communications 8 (1) : 1986. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-017-02086-y 2041-1723 https://scholarbank.nus.edu.sg/handle/10635/178553 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	adenosine phosphate glucose 6 phosphate pyruvate kinase adenosine phosphate glucose glucose 6 phosphate pyruvate kinase energy enzyme activity metabolism metabolite network analysis nutrient sugar tuberculosis allosteric site allosterism amino acid sequence Article carboxy terminal sequence comparative study conformational transition controlled study energy metabolism enzyme activation enzyme activity enzyme kinetics enzyme stability enzyme structure gene expression system glucose metabolism metabolic regulation molecular dynamics Mycobacterium bovis BCG nonhuman nutrient protein protein interaction allosterism chemistry enzyme assay kinetics metabolism metabolome metabolomics molecular docking Mycobacterium bovis Mycobacterium tuberculosis protein domain X ray crystallography Bacteria (microorganisms) Mycobacterium bovis BCG Mycobacterium tuberculosis Adenosine Monophosphate Allosteric Regulation Crystallography, X-Ray Enzyme Assays Glucose Glucose-6-Phosphate Kinetics Metabolome Metabolomics Molecular Docking Simulation Mycobacterium bovis Mycobacterium tuberculosis Protein Domains Pyruvate Kinase
spellingShingle	adenosine phosphate glucose 6 phosphate pyruvate kinase adenosine phosphate glucose glucose 6 phosphate pyruvate kinase energy enzyme activity metabolism metabolite network analysis nutrient sugar tuberculosis allosteric site allosterism amino acid sequence Article carboxy terminal sequence comparative study conformational transition controlled study energy metabolism enzyme activation enzyme activity enzyme kinetics enzyme stability enzyme structure gene expression system glucose metabolism metabolic regulation molecular dynamics Mycobacterium bovis BCG nonhuman nutrient protein protein interaction allosterism chemistry enzyme assay kinetics metabolism metabolome metabolomics molecular docking Mycobacterium bovis Mycobacterium tuberculosis protein domain X ray crystallography Bacteria (microorganisms) Mycobacterium bovis BCG Mycobacterium tuberculosis Adenosine Monophosphate Allosteric Regulation Crystallography, X-Ray Enzyme Assays Glucose Glucose-6-Phosphate Kinetics Metabolome Metabolomics Molecular Docking Simulation Mycobacterium bovis Mycobacterium tuberculosis Protein Domains Pyruvate Kinase Zhong, W Cui, L Goh, B.C Cai, Q Ho, P Chionh, Y.H Yuan, M Sahili, A.E Fothergill-Gilmore, L.A Walkinshaw, M.D Lescar, J Dedon, P.C Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis
description	10.1038/s41467-017-02086-y
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Zhong, W Cui, L Goh, B.C Cai, Q Ho, P Chionh, Y.H Yuan, M Sahili, A.E Fothergill-Gilmore, L.A Walkinshaw, M.D Lescar, J Dedon, P.C
format	Article
author	Zhong, W Cui, L Goh, B.C Cai, Q Ho, P Chionh, Y.H Yuan, M Sahili, A.E Fothergill-Gilmore, L.A Walkinshaw, M.D Lescar, J Dedon, P.C
author_sort	Zhong, W
title	Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis
title_short	Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis
title_full	Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis
title_fullStr	Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis
title_full_unstemmed	Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis
title_sort	allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in mycobacterium tuberculosis
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/178553
_version_	1821181356546195456

Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis

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