SCN5A genetic polymorphisms associated with increased defibrillator shocks in Brugada syndrome

• Main Authors: Makarawate, P, Chaosuwannakit, N, Vannaprasaht, S, Sahasthas, D, Koo, S.H, Lee, E.J.D, Tassaneeyakul, W, Barajas-Martinez, H, Hu, D, Sawanyawisuth, K
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: 2020
• Subjects: Article; Brugada syndrome; clinical article; exon; gene; gene frequency; gene mutation; genetic polymorphism; genetic variability; genotype; heart muscle conduction disturbance; heart ventricle fibrillation; heart ventricle tachycardia; human; implantable cardioverter defibrillator; male; PR interval; priority journal; QRS interval; SCN5A gene; single nucleotide polymorphism; adult; cardioversion; devices; electrocardiography; female; genetic association study; genetic predisposition; genetics; heart muscle conduction system; Kaplan Meier method; middle aged; pathophysiology; phenotype; Thailand; time factor; treatment outcome; university hospital; young adult; SCN5A protein, human; sodium channel Nav1.5; Adult; Brugada Syndrome; Defibrillators, Implantable; Electric Countershock; Electrocardiography; Female; Genetic Association Studies; Genetic Predisposition to Disease; Heart Conduction System; Hospitals, University; Humans; Kaplan-Meier Estimate; Male; Middle Aged; NAV1.5 Voltage-Gated Sodium Channel; Phenotype; Polymorphism, Genetic; Time Factors; Treatment Outcome; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178673
• Institution: National University of Singapore

10.1161/JAHA.116.005009