Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway

• Main Authors: Li, S, Wang, X, Ma, Q.-H, Yang, W.-L, Zhang, X.-G, Dawe, G.S, Xiao, Z.-C
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: 2020
• Subjects: amyloid precursor protein; inhibitory guanine nucleotide binding protein; Scn8a protein, mouse; sodium channel Nav1.6; animal; hippocampus; knockout mouse; MAPK signaling; metabolism; nerve cell; phosphorylation; physiology; protein processing; Xenopus; Amyloid beta-Protein Precursor; Animals; GTP-Binding Protein alpha Subunits, Gi-Go; Hippocampus; MAP Kinase Signaling System; Mice, Knockout; NAV1.6 Voltage-Gated Sodium Channel; Neurons; Phosphorylation; Protein Processing, Post-Translational
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178743
• Institution: National University of Singapore

10.1038/srep39320