Sphingosine-1-phosphate receptor 1 regulates cardiac function by modulating Ca2+ sensitivity and Na+/H+ exchange and mediates protection by ischemic preconditioning

• Main Authors: Keul, P, van Borren, M.M.G.J, Ghanem, A, Müller, F.U, Baartscheer, A, Verkerk, A.O, Stümpel, F, Schulte, J.S, Hamdani, N, Linke, W.A, van Loenen, P, Matus, M, Schmitz, W, Stypmann, J, Tiemann, K, Ravesloot, J.-H, Alewijnse, A.E, Hermann, S, Spijkers, L.J.A, Hiller, K.-H, Herr, D, Heusch, G, Schäfers, M, Peters, S.L.M, Chun, J, Levkau, B
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: 2020
• Subjects: adenylate cyclase; calcium ion; dobutamine; myosin binding protein C; myosin light chain 2; protein kinase B; sodium ion; sodium proton exchange protein 1; sphingosine 1 phosphate receptor; sphingosine 1 phosphate receptor 1; sphingosine kinase; troponin I; unclassified drug; calcium; cardiac myosin; carrier protein; growth factor-activatable Na-H exchanger NHE-1; myosin light chain; myosin-binding protein C; S1pr1 protein, mouse; sodium proton exchange protein; adrenergic system; animal cell; animal experiment; animal model; animal tissue; Article; cardiac muscle cell; cardiomyopathy; cell isolation; controlled study; diastole; enzyme activation; enzyme inhibition; female; heart function; heart infarction prevention; heart muscle contractility; heart muscle fiber membrane; heart muscle relaxation; male; mouse; nonhuman; premature mortality; priority journal; protein depletion; protein function; protein phosphorylation; proton sodium exchange; regulatory mechanism; reproducibility; sarcomere length; sodium cell level; systole; action potential; animal; antagonists and inhibitors; diagnostic imaging; drug effects; echocardiography; genetics; knockout mouse; metabolism; myocardial ischemia reperfusion injury; nuclear magnetic resonance imaging; phosphorylation; positron emission tomography; real time polymerase chain reaction; sarcomere; Western blotting; Action Potentials; Adenylyl Cyclases; Animals; Blotting, Western; Calcium; Cardiac Myosins; Cardiomyopathies; Carrier Proteins; Echocardiography; Ischemic Preconditioning, Myocardial; Magnetic Resonance Imaging; Mice; Mice, Knockout; Myocardial Reperfusion Injury; Myocytes, Cardiac; Myosin Light Chains; Phosphorylation; Positron-Emission Tomography; Real-Time Polymerase Chain Reaction; Receptors, Lysosphingolipid; Sarcomeres; Sodium-Hydrogen Exchangers; Troponin I
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/178907
• Institution: National University of Singapore

10.1161/JAHA.116.003393