Impact of immunopathology on the antituberculous activity of pyrazinamide

• Main Authors: Blanc, L, Sarathy, J.P, Cabrera, N.A, O’Brien, P, Dias Freedman, I, Mina, M, Sacchettini, J, Savic, R.M, Gengenbacher, M, Podell, B.K, Prideaux, B, Ioerger, T, Dick, T, Dartois, V
• Other Authors: MEDICINE
• Format: Article
• Published: Rockefeller University Press 2020
• Subjects: pyrazinamide; tuberculostatic agent; animal cell; animal experiment; animal model; animal tissue; area under the curve; Article; bacterial load; bactericidal activity; blood sampling; chronic disease; colony forming unit; controlled study; DNA extraction; drug blood level; drug efficacy; drug potency; genetic heterogeneity; human; immune response; immunocompetent cell; immunopathology; limit of detection; lung lesion; lung parenchyma; matrix-assisted laser desorption-ionization mass spectrometry; maximum concentration; maximum plasma concentration; minimum inhibitory concentration; Mycobacterium tuberculosis; nonhuman; priority journal; rabbit model; tandem mass spectrometry; treatment duration; tuberculosis; whole genome sequencing; animal; disease model; drug effect; female; immunology; Leporidae; metabolism; microbial viability; microbiology; necrosis; neutrophil; pathology; physiology; Animals; Antitubercular Agents; Disease Models, Animal; Female; Humans; Microbial Viability; Necrosis; Neutrophils; Pyrazinamide; Rabbits; Tuberculosis
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179024
• Institution: National University of Singapore

10.1084/jem.20180518