Mouse saliva inhibits transit of influenza virus to the lower respiratory tract by efficiently blocking influenza virus neuraminidase activity

• Main Authors: Gilbertson, B, Ng, W.C, Crawford, S, McKimm-Breschkin, J.L, Brown, L.E
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: American Society for Microbiology 2020
• Subjects: membrane protein; sialidase inhibitor; viral protein; virus sialidase; NA protein, influenza A virus; sialidase; amino acid sequence; animal experiment; animal model; antiviral susceptibility; Article; controlled study; enzyme active site; enzyme activity; enzyme inhibition; enzyme substrate; human; human cell; in vitro study; Influenza A virus (H3N2); Influenza virus; lower respiratory tract; mouse; nonhuman; priority journal; reverse genetics; saliva; virus hybrid; virus inhibition; virus resistance; virus strain; animal; antagonists and inhibitors; disease model; dog; enzymology; genetics; immunology; innate immunity; lung; MDCK cell line; orthomyxovirus infection; respiratory system; virology; Animals; Disease Models, Animal; Dogs; Immunity, Innate; Influenza A Virus, H3N2 Subtype; Lung; Madin Darby Canine Kidney Cells; Mice; Neuraminidase; Orthomyxoviridae Infections; Respiratory System; Reverse Genetics; Saliva; Viral Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179195
• Institution: National University of Singapore

10.1128/JVI.00145-17