Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma

10.1172/JCI87583

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Main Authors:	Kent, L.N, Bae, S, Tsai, S.-Y, Tang, X, Srivastava, A, Koivisto, C, Martin, C.K, Ridolfi, E, Miller, G.C, Zorko, S.M, Plevris, E, Hadjiyannis, Y, Perez, M, Nolan, E, Kladney, R, Westendorp, B, De Bruin, A, Fernandez, S, Rosol, T.J, Pohar, K.S, Pipas, J.M, Leone, G
Other Authors:	PHYSIOLOGY
Format:	Article
Published:	American Society for Clinical Investigation 2020
Subjects:	transcription factor E2F1 transcription factor E2F3 transcriptome E2f1 protein, mouse E2f3 protein, mouse tumor protein animal model animal tissue Article cancer incidence cancer prognosis cancer survival chromatin chromatin immunoprecipitation controlled study copy number variation disease course DNA microarray e2f1 gene e2f3 gene epigenetics female gain of function mutation gene gene dosage gene expression gene locus gene mapping gene mutation genetic gain genetic transcription genetic variability histopathology human human cell immunoblotting immunohistochemistry liver cell carcinoma male mouse mutation rate nonhuman polymerase chain reaction protein expression tumor volume animal genetics knockout mouse liver tumor metabolism tumor gene Animals Carcinoma, Hepatocellular E2F1 Transcription Factor E2F3 Transcription Factor Gene Dosage Genes, Neoplasm Humans Liver Neoplasms Mice Mice, Knockout Neoplasm Proteins
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179227
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1792272024-04-04T01:11:03Z Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma Kent, L.N Bae, S Tsai, S.-Y Tang, X Srivastava, A Koivisto, C Martin, C.K Ridolfi, E Miller, G.C Zorko, S.M Plevris, E Hadjiyannis, Y Perez, M Nolan, E Kladney, R Westendorp, B De Bruin, A Fernandez, S Rosol, T.J Pohar, K.S Pipas, J.M Leone, G PHYSIOLOGY transcription factor E2F1 transcription factor E2F3 transcriptome E2f1 protein, mouse E2f3 protein, mouse transcription factor E2F1 transcription factor E2F3 tumor protein animal model animal tissue Article cancer incidence cancer prognosis cancer survival chromatin chromatin immunoprecipitation controlled study copy number variation disease course DNA microarray e2f1 gene e2f3 gene epigenetics female gain of function mutation gene gene dosage gene expression gene locus gene mapping gene mutation genetic gain genetic transcription genetic variability histopathology human human cell immunoblotting immunohistochemistry liver cell carcinoma male mouse mutation rate nonhuman polymerase chain reaction protein expression tumor volume animal genetics knockout mouse liver tumor metabolism tumor gene Animals Carcinoma, Hepatocellular E2F1 Transcription Factor E2F3 Transcription Factor Gene Dosage Genes, Neoplasm Humans Liver Neoplasms Mice Mice, Knockout Neoplasm Proteins 10.1172/JCI87583 Journal of Clinical Investigation 127 3 830-842 2020-10-23T02:33:05Z 2020-10-23T02:33:05Z 2017 Article Kent, L.N, Bae, S, Tsai, S.-Y, Tang, X, Srivastava, A, Koivisto, C, Martin, C.K, Ridolfi, E, Miller, G.C, Zorko, S.M, Plevris, E, Hadjiyannis, Y, Perez, M, Nolan, E, Kladney, R, Westendorp, B, De Bruin, A, Fernandez, S, Rosol, T.J, Pohar, K.S, Pipas, J.M, Leone, G (2017). Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma. Journal of Clinical Investigation 127 (3) : 830-842. ScholarBank@NUS Repository. https://doi.org/10.1172/JCI87583 00219738 https://scholarbank.nus.edu.sg/handle/10635/179227 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ American Society for Clinical Investigation Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	transcription factor E2F1 transcription factor E2F3 transcriptome E2f1 protein, mouse E2f3 protein, mouse transcription factor E2F1 transcription factor E2F3 tumor protein animal model animal tissue Article cancer incidence cancer prognosis cancer survival chromatin chromatin immunoprecipitation controlled study copy number variation disease course DNA microarray e2f1 gene e2f3 gene epigenetics female gain of function mutation gene gene dosage gene expression gene locus gene mapping gene mutation genetic gain genetic transcription genetic variability histopathology human human cell immunoblotting immunohistochemistry liver cell carcinoma male mouse mutation rate nonhuman polymerase chain reaction protein expression tumor volume animal genetics knockout mouse liver tumor metabolism tumor gene Animals Carcinoma, Hepatocellular E2F1 Transcription Factor E2F3 Transcription Factor Gene Dosage Genes, Neoplasm Humans Liver Neoplasms Mice Mice, Knockout Neoplasm Proteins
spellingShingle	transcription factor E2F1 transcription factor E2F3 transcriptome E2f1 protein, mouse E2f3 protein, mouse transcription factor E2F1 transcription factor E2F3 tumor protein animal model animal tissue Article cancer incidence cancer prognosis cancer survival chromatin chromatin immunoprecipitation controlled study copy number variation disease course DNA microarray e2f1 gene e2f3 gene epigenetics female gain of function mutation gene gene dosage gene expression gene locus gene mapping gene mutation genetic gain genetic transcription genetic variability histopathology human human cell immunoblotting immunohistochemistry liver cell carcinoma male mouse mutation rate nonhuman polymerase chain reaction protein expression tumor volume animal genetics knockout mouse liver tumor metabolism tumor gene Animals Carcinoma, Hepatocellular E2F1 Transcription Factor E2F3 Transcription Factor Gene Dosage Genes, Neoplasm Humans Liver Neoplasms Mice Mice, Knockout Neoplasm Proteins Kent, L.N Bae, S Tsai, S.-Y Tang, X Srivastava, A Koivisto, C Martin, C.K Ridolfi, E Miller, G.C Zorko, S.M Plevris, E Hadjiyannis, Y Perez, M Nolan, E Kladney, R Westendorp, B De Bruin, A Fernandez, S Rosol, T.J Pohar, K.S Pipas, J.M Leone, G Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma
description	10.1172/JCI87583
author2	PHYSIOLOGY
author_facet	PHYSIOLOGY Kent, L.N Bae, S Tsai, S.-Y Tang, X Srivastava, A Koivisto, C Martin, C.K Ridolfi, E Miller, G.C Zorko, S.M Plevris, E Hadjiyannis, Y Perez, M Nolan, E Kladney, R Westendorp, B De Bruin, A Fernandez, S Rosol, T.J Pohar, K.S Pipas, J.M Leone, G
format	Article
author	Kent, L.N Bae, S Tsai, S.-Y Tang, X Srivastava, A Koivisto, C Martin, C.K Ridolfi, E Miller, G.C Zorko, S.M Plevris, E Hadjiyannis, Y Perez, M Nolan, E Kladney, R Westendorp, B De Bruin, A Fernandez, S Rosol, T.J Pohar, K.S Pipas, J.M Leone, G
author_sort	Kent, L.N
title	Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma
title_short	Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma
title_full	Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma
title_fullStr	Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma
title_full_unstemmed	Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma
title_sort	dosage-dependent copy number gains in e2f1 and e2f3 drive hepatocellular carcinoma
publisher	American Society for Clinical Investigation
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/179227
_version_	1795374478900854784

Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma

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