High-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures

10.1007/s00204-015-1638-y

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Main Authors:	Su, R, Xiong, S, Zink, D, Loo, L.-H
Other Authors:	DEPT OF PHARMACOLOGY
Format:	Article
Published:	Springer Verlag 2020
Subjects:	cisplatin DNA A lithium chloride RNA xenobiotic agent molecular library mutagenic agent Article cell count cell death chemical structure chromatin controlled study DNA damage DNA damage response gene expression gene expression profiling human human cell immortalized cell line in vivo study kidney tubule cell machine learning nephrotoxicity phenotype priority journal RNA sequence biology cell culture chemistry chromatin assembly and disassembly cytology cytoskeleton drug effects feasibility study high throughput screening kidney proximal tubule laboratory automation molecular model osmolarity preclinical study transformed cell line validation study Automation, Laboratory Cell Death Cell Line, Transformed Cells, Cultured Chromatin Assembly and Disassembly Computational Biology Cytoskeleton DNA Damage Drug Evaluation, Preclinical Feasibility Studies High-Throughput Screening Assays Humans Kidney Tubules, Proximal Machine Learning Models, Molecular Molecular Structure Mutagens Osmolar Concentration Small Molecule Libraries Xenobiotics
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179284
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Institution:	National University of Singapore

id	sg-nus-scholar.10635-179284
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spelling	sg-nus-scholar.10635-1792842023-10-31T22:10:14Z High-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures Su, R Xiong, S Zink, D Loo, L.-H DEPT OF PHARMACOLOGY cisplatin DNA A lithium chloride RNA xenobiotic agent molecular library mutagenic agent xenobiotic agent Article cell count cell death chemical structure chromatin controlled study DNA damage DNA damage response gene expression gene expression profiling human human cell immortalized cell line in vivo study kidney tubule cell machine learning nephrotoxicity phenotype priority journal RNA sequence biology cell culture chemical structure chemistry chromatin assembly and disassembly cytology cytoskeleton drug effects feasibility study high throughput screening kidney proximal tubule laboratory automation molecular library molecular model osmolarity preclinical study transformed cell line validation study Automation, Laboratory Cell Death Cell Line, Transformed Cells, Cultured Chromatin Assembly and Disassembly Computational Biology Cytoskeleton DNA Damage Drug Evaluation, Preclinical Feasibility Studies High-Throughput Screening Assays Humans Kidney Tubules, Proximal Machine Learning Models, Molecular Molecular Structure Mutagens Osmolar Concentration Small Molecule Libraries Xenobiotics 10.1007/s00204-015-1638-y Archives of Toxicology 90 11 2793-2808 2020-10-23T02:44:07Z 2020-10-23T02:44:07Z 2016 Article Su, R, Xiong, S, Zink, D, Loo, L.-H (2016). High-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures. Archives of Toxicology 90 (11) : 2793-2808. ScholarBank@NUS Repository. https://doi.org/10.1007/s00204-015-1638-y 0340-5761 https://scholarbank.nus.edu.sg/handle/10635/179284 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Springer Verlag Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	cisplatin DNA A lithium chloride RNA xenobiotic agent molecular library mutagenic agent xenobiotic agent Article cell count cell death chemical structure chromatin controlled study DNA damage DNA damage response gene expression gene expression profiling human human cell immortalized cell line in vivo study kidney tubule cell machine learning nephrotoxicity phenotype priority journal RNA sequence biology cell culture chemical structure chemistry chromatin assembly and disassembly cytology cytoskeleton drug effects feasibility study high throughput screening kidney proximal tubule laboratory automation molecular library molecular model osmolarity preclinical study transformed cell line validation study Automation, Laboratory Cell Death Cell Line, Transformed Cells, Cultured Chromatin Assembly and Disassembly Computational Biology Cytoskeleton DNA Damage Drug Evaluation, Preclinical Feasibility Studies High-Throughput Screening Assays Humans Kidney Tubules, Proximal Machine Learning Models, Molecular Molecular Structure Mutagens Osmolar Concentration Small Molecule Libraries Xenobiotics
spellingShingle	cisplatin DNA A lithium chloride RNA xenobiotic agent molecular library mutagenic agent xenobiotic agent Article cell count cell death chemical structure chromatin controlled study DNA damage DNA damage response gene expression gene expression profiling human human cell immortalized cell line in vivo study kidney tubule cell machine learning nephrotoxicity phenotype priority journal RNA sequence biology cell culture chemical structure chemistry chromatin assembly and disassembly cytology cytoskeleton drug effects feasibility study high throughput screening kidney proximal tubule laboratory automation molecular library molecular model osmolarity preclinical study transformed cell line validation study Automation, Laboratory Cell Death Cell Line, Transformed Cells, Cultured Chromatin Assembly and Disassembly Computational Biology Cytoskeleton DNA Damage Drug Evaluation, Preclinical Feasibility Studies High-Throughput Screening Assays Humans Kidney Tubules, Proximal Machine Learning Models, Molecular Molecular Structure Mutagens Osmolar Concentration Small Molecule Libraries Xenobiotics Su, R Xiong, S Zink, D Loo, L.-H High-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures
description	10.1007/s00204-015-1638-y
author2	DEPT OF PHARMACOLOGY
author_facet	DEPT OF PHARMACOLOGY Su, R Xiong, S Zink, D Loo, L.-H
format	Article
author	Su, R Xiong, S Zink, D Loo, L.-H
author_sort	Su, R
title	High-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures
title_short	High-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures
title_full	High-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures
title_fullStr	High-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures
title_full_unstemmed	High-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures
title_sort	high-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures
publisher	Springer Verlag
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/179284
_version_	1781792334053113856

High-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures

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