The pro-fibrotic properties of transforming growth factor on human fibroblasts are counteracted by caffeic acid by inhibiting myofibroblast formation and collagen synthesis

• Main Authors: Mia, M.M, Bank, R.A
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Springer Verlag 2020
• Subjects: alpha smooth muscle actin; caffeic acid phenethyl ester; collagen type 1; fibronectin; messenger RNA; Smad2 protein; Smad3 protein; tenascin; transcription factor Gli1; transcription factor Gli2; transcription factor Snail; transcription factor Snail1; transforming growth factor beta1; unclassified drug; ACTA2 protein, human; actin; actin binding protein; caffeic acid derivative; muscle protein; phenethyl alcohol; PLOD2 protein, human; procollagen lysine 2 oxoglutarate 5 dioxygenase; Smad protein; transcription factor; transgelin; ACTA2 gene; adult; antifibrotic activity; Article; cellular distribution; cellular, subcellular and molecular biological phenomena and functions; collagen synthesis; controlled study; drug activity; drug mechanism; gene; gene expression regulation; GLI1 gene; GLI2 gene; human; human cell; lung fibroblast; molecular dynamics; myofibroblast formation; PLOD2 gene; priority journal; protein expression; protein function; skin fibroblast; TAGLN gene; upregulation; analogs and derivatives; biosynthesis; cell nucleus; drug effects; fibroblast; fibrosis; genetics; metabolism; myofibroblast; pathology; protein transport; young adult; Actins; Adult; Caffeic Acids; Cell Nucleus; Collagen Type I; Fibroblasts; Fibronectins; Fibrosis; Gene Expression Regulation; Humans; Microfilament Proteins; Muscle Proteins; Myofibroblasts; Phenylethyl Alcohol; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase; Protein Transport; RNA, Messenger; Smad Proteins; Tenascin; Transcription Factors; Transforming Growth Factor beta1; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179593
• Institution: National University of Singapore

10.1007/s00441-015-2285-6