Roflumilast, a Type 4 phosphodiesterase inhibitor, shows promising adjunctive, host-directed therapeutic activity in a mouse model of tuberculosis

10.1128/AAC.02145-15

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Main Authors:	Maiga, M.C, Ahidjo, B.A, Maiga, M, Bishai, W.R
Other Authors:	MICROBIOLOGY AND IMMUNOLOGY
Format:	Article
Published:	American Society for Microbiology 2020
Subjects:	gamma interferon interleukin 1beta isoniazid roflumilast tumor necrosis factor alpha aminopyridine derivative benzamide derivative cyclopropane derivative phosphodiesterase IV inhibitor tuberculostatic agent tumor necrosis factor animal model antibacterial activity Article bacterial clearance chronic obstructive lung disease controlled study cytokine production female food and drug administration median survival time mortality mouse nonhuman priority journal tissue distribution treatment outcome tuberculosis animal Bagg albino mouse biosynthesis disease model drug effects growth, development and aging immunology lung microbiology Mycobacterium tuberculosis survival analysis Tuberculosis, Pulmonary Aminopyridines Animals Antitubercular Agents Benzamides Cyclopropanes Disease Models, Animal Female Interferon-gamma Interleukin-1beta Isoniazid Lung Mice Mice, Inbred BALB C Phosphodiesterase 4 Inhibitors Survival Analysis Tumor Necrosis Factor-alpha
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179634
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1796342024-03-27T08:11:33Z Roflumilast, a Type 4 phosphodiesterase inhibitor, shows promising adjunctive, host-directed therapeutic activity in a mouse model of tuberculosis Maiga, M.C Ahidjo, B.A Maiga, M Bishai, W.R MICROBIOLOGY AND IMMUNOLOGY gamma interferon interleukin 1beta isoniazid roflumilast tumor necrosis factor alpha aminopyridine derivative benzamide derivative cyclopropane derivative gamma interferon interleukin 1beta isoniazid phosphodiesterase IV inhibitor roflumilast tuberculostatic agent tumor necrosis factor animal model antibacterial activity Article bacterial clearance chronic obstructive lung disease controlled study cytokine production female food and drug administration median survival time mortality mouse nonhuman priority journal tissue distribution treatment outcome tuberculosis animal Bagg albino mouse biosynthesis disease model drug effects growth, development and aging immunology lung microbiology Mycobacterium tuberculosis survival analysis Tuberculosis, Pulmonary Aminopyridines Animals Antitubercular Agents Benzamides Cyclopropanes Disease Models, Animal Female Interferon-gamma Interleukin-1beta Isoniazid Lung Mice Mice, Inbred BALB C Mycobacterium tuberculosis Phosphodiesterase 4 Inhibitors Survival Analysis Tuberculosis, Pulmonary Tumor Necrosis Factor-alpha 10.1128/AAC.02145-15 Antimicrobial Agents and Chemotherapy 59 12 7888-7890 2020-10-23T08:07:37Z 2020-10-23T08:07:37Z 2015 Article Maiga, M.C, Ahidjo, B.A, Maiga, M, Bishai, W.R (2015). Roflumilast, a Type 4 phosphodiesterase inhibitor, shows promising adjunctive, host-directed therapeutic activity in a mouse model of tuberculosis. Antimicrobial Agents and Chemotherapy 59 (12) : 7888-7890. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.02145-15 0066-4804 https://scholarbank.nus.edu.sg/handle/10635/179634 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ American Society for Microbiology Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	gamma interferon interleukin 1beta isoniazid roflumilast tumor necrosis factor alpha aminopyridine derivative benzamide derivative cyclopropane derivative gamma interferon interleukin 1beta isoniazid phosphodiesterase IV inhibitor roflumilast tuberculostatic agent tumor necrosis factor animal model antibacterial activity Article bacterial clearance chronic obstructive lung disease controlled study cytokine production female food and drug administration median survival time mortality mouse nonhuman priority journal tissue distribution treatment outcome tuberculosis animal Bagg albino mouse biosynthesis disease model drug effects growth, development and aging immunology lung microbiology Mycobacterium tuberculosis survival analysis Tuberculosis, Pulmonary Aminopyridines Animals Antitubercular Agents Benzamides Cyclopropanes Disease Models, Animal Female Interferon-gamma Interleukin-1beta Isoniazid Lung Mice Mice, Inbred BALB C Mycobacterium tuberculosis Phosphodiesterase 4 Inhibitors Survival Analysis Tuberculosis, Pulmonary Tumor Necrosis Factor-alpha
spellingShingle	gamma interferon interleukin 1beta isoniazid roflumilast tumor necrosis factor alpha aminopyridine derivative benzamide derivative cyclopropane derivative gamma interferon interleukin 1beta isoniazid phosphodiesterase IV inhibitor roflumilast tuberculostatic agent tumor necrosis factor animal model antibacterial activity Article bacterial clearance chronic obstructive lung disease controlled study cytokine production female food and drug administration median survival time mortality mouse nonhuman priority journal tissue distribution treatment outcome tuberculosis animal Bagg albino mouse biosynthesis disease model drug effects growth, development and aging immunology lung microbiology Mycobacterium tuberculosis survival analysis Tuberculosis, Pulmonary Aminopyridines Animals Antitubercular Agents Benzamides Cyclopropanes Disease Models, Animal Female Interferon-gamma Interleukin-1beta Isoniazid Lung Mice Mice, Inbred BALB C Mycobacterium tuberculosis Phosphodiesterase 4 Inhibitors Survival Analysis Tuberculosis, Pulmonary Tumor Necrosis Factor-alpha Maiga, M.C Ahidjo, B.A Maiga, M Bishai, W.R Roflumilast, a Type 4 phosphodiesterase inhibitor, shows promising adjunctive, host-directed therapeutic activity in a mouse model of tuberculosis
description	10.1128/AAC.02145-15
author2	MICROBIOLOGY AND IMMUNOLOGY
author_facet	MICROBIOLOGY AND IMMUNOLOGY Maiga, M.C Ahidjo, B.A Maiga, M Bishai, W.R
format	Article
author	Maiga, M.C Ahidjo, B.A Maiga, M Bishai, W.R
author_sort	Maiga, M.C
title	Roflumilast, a Type 4 phosphodiesterase inhibitor, shows promising adjunctive, host-directed therapeutic activity in a mouse model of tuberculosis
title_short	Roflumilast, a Type 4 phosphodiesterase inhibitor, shows promising adjunctive, host-directed therapeutic activity in a mouse model of tuberculosis
title_full	Roflumilast, a Type 4 phosphodiesterase inhibitor, shows promising adjunctive, host-directed therapeutic activity in a mouse model of tuberculosis
title_fullStr	Roflumilast, a Type 4 phosphodiesterase inhibitor, shows promising adjunctive, host-directed therapeutic activity in a mouse model of tuberculosis
title_full_unstemmed	Roflumilast, a Type 4 phosphodiesterase inhibitor, shows promising adjunctive, host-directed therapeutic activity in a mouse model of tuberculosis
title_sort	roflumilast, a type 4 phosphodiesterase inhibitor, shows promising adjunctive, host-directed therapeutic activity in a mouse model of tuberculosis
publisher	American Society for Microbiology
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/179634
_version_	1795301253082775552

Roflumilast, a Type 4 phosphodiesterase inhibitor, shows promising adjunctive, host-directed therapeutic activity in a mouse model of tuberculosis

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