Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1

Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1

10.1038/ncomms15466

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Bibliographic Details
Main Authors:	Pasutto, F, Zenkel, M, Hoja, U, Berner, D, Uebe, S, Ferrazzi, F, Schödel, J, Liravi, P, Ozaki, M, Paoli, D, Frezzotti, P, Mizoguchi, T, Nakano, S, Kubota, T, Manabe, S, Salvi, E, Manunta, P, Cusi, D, Gieger, C, Wichmann, H.-E, Aung, T, Khor, C.C, Kruse, F.E, Reis, A, Schlötzer-Schrehardt, U
Other Authors:	OPHTHALMOLOGY
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	complementary DNA DNA genomic DNA hepatocyte nuclear factor 4 hepatocyte nuclear factor 4alpha heterodimer immunoglobulin enhancer binding protein immunoglobulin G lysyl oxidase like 1 messenger RNA myogenin nf 1 protein NR2F1 protein oligonucleotide peroxisome proliferator activated receptor alpha peroxisome proliferator activated receptor gamma protein puromycin retinoic acid retinoid X receptor alpha RNA polymerase II roaz protein small interfering RNA transcription factor unclassified drug zid protein LOXL1 protein, human oxidoreductase protein binding allele cardiovascular disease chemical binding data assimilation enzyme activity genetic variation risk factor allelic imbalance alternative RNA splicing Article binding affinity binding site biotinylation chromosome 15 cohort analysis comparative study controlled study DNA binding DNA probe DNA protein complex enhancer region gel mobility shift assay gene activation gene control gene expression gene locus genetic transfection genetic variability genome-wide association study genotype genotype phenotype correlation glaucoma haplotype human human tissue in vitro study intron luciferase assay major clinical study molecular size nonsense mediated mRNA decay polymorphic locus promoter region protein expression pseudoexfoliation quantitative analysis reverse transcription polymerase chain reaction RNA analysis single nucleotide polymorphism steady state transient transfection upregulation aged case control study chemistry chromatin complication female genetic predisposition genetics Germany Italy Japan male middle aged very elderly Aged Aged, 80 and over Alleles Alternative Splicing Amino Acid Oxidoreductases Case-Control Studies Chromatin Enhancer Elements, Genetic Exfoliation Syndrome Female Genetic Predisposition to Disease Genome-Wide Association Study Genotype Glaucoma Humans Introns Male Middle Aged Polymorphism, Single Nucleotide Protein Binding Retinoid X Receptor alpha
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179715
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Institution:	National University of Singapore

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