A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer

• Main Authors: Preca, B.-T, Bajdak, K, Mock, K, Lehmann, W, Sundararajan, V, Bronsert, P, Matzge-Ogi, A, Orian-Rousseau, V, Brabletz, S, Brabletz, T, Maurer, J, Stemmler, M.P
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: 2020
• Subjects: epithelial splicing regulatory protein 1; Hermes antigen; hyaluronic acid; hyaluronic acid synthase 2; proteoglycan; regulator protein; synthetase; transcription factor ZEB1; transforming growth factor beta; unclassified drug; glucuronosyltransferase; HAS2 protein, human; ZEB1 protein, human; Article; bone metastasis; breast cancer; breast cancer cell line; cancer growth; cancer prognosis; cancer recurrence; cell differentiation; controlled study; correlational study; epithelial mesenchymal transition; feedback system; gene; gene activation; gene expression; genetic association; HAS2 gene; human; human cell; human tissue; in vitro study; osteoclast; osteolysis; positive feedback loop; protein function; tumor growth; ZEB1 gene; breast tumor; chromatin immunoprecipitation; enzyme linked immunosorbent assay; female; fluorescent antibody technique; gene expression regulation; immunohistochemistry; Kaplan Meier method; metabolism; pathology; physiological feedback; physiology; polymerase chain reaction; tumor cell line; tumor invasion; Western blotting; Blotting, Western; Breast Neoplasms; Cell Differentiation; Cell Line, Tumor; Chromatin Immunoprecipitation; Enzyme-Linked Immunosorbent Assay; Epithelial-Mesenchymal Transition; Feedback, Physiological; Female; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Glucuronosyltransferase; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Neoplasm Invasiveness; Osteoclasts; Polymerase Chain Reaction; Zinc Finger E-box-Binding Homeobox 1
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179888
• Institution: National University of Singapore

10.18632/oncotarget.14563