Combinatorial epigenetic therapy in diffuse large B cell lymphoma pre-clinical models and patients

• Main Authors: Pera, B, Tang, T, Marullo, R, Yang, S.-N, Ahn, H, Patel, J, Elstrom, R, Ruan, J, Furman, R, Leonard, J, Cerchietti, L, Martin, P
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: azacitidine; bendamustine; bortezomib; brentuximab vedotin; carboplatin; carmustine; chlormethine; cisplatin; cyclophosphamide; cytarabine; decitabine; dexamethasone; DNA methyltransferase inhibitor; doxorubicin; etoposide; fluorodeoxyglucose f 18; histone deacetylase inhibitor; ifosfamide; melphalan; methylprednisolone; prednisolone; prednisone; procarbazine; protein p21; rituximab; veltuzumab; vincristine; vorinostat; antineoplastic agent; hydroxamic acid; adult; aged; anemia; animal experiment; animal model; antineoplastic activity; Article; autologous stem cell transplantation; B cell lymphoma; cancer mortality; cancer radiotherapy; cancer recurrence; chemosensitization; clinical article; computer assisted emission tomography; controlled study; diarrhea; disease model; drug dose comparison; drug potentiation; drug safety; drug tolerability; epigenetics; fatigue; female; fever; gastrointestinal disease; gene therapy; hematologic disease; human; human cell; hyperamylasemia; hyperbilirubinemia; hyperglycemia; hypoglycemia; in vitro study; in vivo study; kidney dysfunction; large cell lymphoma; leukopenia; male; metabolic disorder; mouse; multiple cycle treatment; nausea; neutropenia; nonhuman; overall survival; phase 1 clinical trial; priority journal; thrombocytopenia; thromboembolism; treatment outcome; treatment response; very elderly; vomiting; analogs and derivatives; clinical trial; DNA methylation; drug effects; genetic epigenesis; Lymphoma, Large B-Cell, Diffuse; middle aged; tumor cell line; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Line, Tumor; DNA Methylation; Epigenesis, Genetic; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Middle Aged; Treatment Outcome
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179920
• Institution: National University of Singapore

10.1186/s13148-016-0245-y