Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance

Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance

10.1186/s12916-016-0575-9

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Bibliographic Details
Main Authors:	Phelan, J, Coll, F, McNerney, R, Ascher, D.B, Pires, D.E, Furnham, N, Coeck, N, Hill-Cawthorne, G.A, Nair, M.B, Mallard, K, Ramsay, A, Campino, S, Hibberd, M.L, Pain, A, Rigouts, L, Clark, T.G
Other Authors:	MICROBIOLOGY AND IMMUNOLOGY
Format:	Article
Published:	2020
Subjects:	aminosalicylic acid capreomycin ethambutol ethionamide isoniazid ofloxacin rifampicin streptomycin tuberculostatic agent bacterial protein Article bacterial gene bacterial genome bacterium isolate binding site controlled study convergent evolution drug efficacy drug resistant tuberculosis gene mutation genetic association study genetic polymorphism minimum inhibitory concentration Mycobacterium tuberculosis nonhuman patient care protein stability protein structure tuberculosis control whole genome sequencing chemistry DNA sequence genetics genome-wide association study human isolation and purification metabolism microbial sensitivity test microbiology molecular model multidrug resistance mutation protein conformation Tuberculosis, Multidrug-Resistant Antitubercular Agents Bacterial Proteins Drug Resistance, Multiple, Bacterial Genome, Bacterial Genome-Wide Association Study Humans Isoniazid Microbial Sensitivity Tests Models, Molecular Mutation Protein Conformation Sequence Analysis, DNA
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/179956
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Institution:	National University of Singapore

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