Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1

• Main Authors: Bai, B, Man, A.W.C, Kangmin Yang, State Key Laboratory of Pharmaceutical Biotechnology, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, Yumeng Guo, State Key Laboratory of Pharmaceutical Biotechnology, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, Cheng Xu, State Key Laboratory of Pharmaceutical Biotechnology, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, Tse, H.-F, Han, W, Bloksgaard, M, De Mey, J.G.R, Vanhoutte, P.M, Xu, A, Wang, Y
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Impact Journals LLC 2020
• Subjects: endothelial nitric oxide synthase; HECT and RLD domain containing E3 ubiquitin protein ligase 2; protein kinase; protein kinase LKB1; sirtuin 1; transforming growth factor beta1; unclassified drug; guanine nucleotide exchange factor; HERC2 protein, human; protein serine threonine kinase; SIRT1 protein, human; STK11 protein, human; ubiquitin; aging; animal cell; Article; binding affinity; binding site; bioaccumulation; cell aging; cell proliferation; chromatin immunoprecipitation; complex formation; controlled study; down regulation; gene; gene function; gene identification; HECT and RLD domain containing E3 ubiquitin protein ligase 2 gene; human; human cell; in vitro study; molecular dynamics; mouse; nonhuman; polymerase chain reaction; protein binding; protein determination; protein function; protein protein interaction; quantitative analysis; sirtuin 1 gene; site directed mutagenesis; vascular aging; vascular remodeling; vascular smooth muscle cell; 3T3-L1 cell line; acetylation; animal; artery; carotid artery; chemistry; endothelium cell; genetics; homeostasis; metabolism; pathology; protein processing; transgenic mouse; tumor cell line; vascular endothelium; vascular smooth muscle; 3T3-L1 Cells; Acetylation; Animals; Arteries; Carotid Arteries; Cell Line, Tumor; Endothelial Cells; Endothelium, Vascular; Guanine Nucleotide Exchange Factors; Homeostasis; Humans; Mice; Mice, Transgenic; Muscle, Smooth, Vascular; Mutagenesis, Site-Directed; Nitric Oxide Synthase Type III; Protein Processing, Post-Translational; Protein-Serine-Threonine Kinases; Sirtuin 1; Ubiquitin; Vascular Remodeling
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180387
• Institution: National University of Singapore

10.18632/oncotarget.9687