RILP suppresses invasion of breast cancer cells by modulating the activity of RalA through interaction with RalGDS

• Main Authors: Wang, Z, Zhou, Y, Hu, X, Chen, W, Lin, X, Sun, L, Xu, X, Hong, W, Wang, T
• Other Authors: INSTITUTE OF MOLECULAR & CELL BIOLOGY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: guanine nucleotide exchange factor; mitogen activated protein kinase; protein; protein kinase B; rab7 interacting lysosomal protein; rala protein; short hairpin RNA; unclassified drug; protein binding; Ral protein; RALA protein, human; RILP protein, human; signal transducing adaptor protein; actin filament; amino terminal sequence; Article; breast cancer; breast cancer cell line; cell behavior assay; cell invasion; cell lysate; cell proliferation; controlled study; cytoplasm; endosome; enzyme phosphorylation; gene overexpression; gene silencing; human; human cell; immunofluorescence microscopy; immunoprecipitation; migration inhibition; nonhuman; priority journal; reverse transcription polymerase chain reaction; RNA interference; signal transduction; transwell assay; Western blotting; wound healing migration assay; breast tumor; cell motion; chemistry; female; MCF-7 cell line; metabolism; pathology; physiology; protein domain; protein transport; tumor invasion; Adaptor Proteins, Signal Transducing; Breast Neoplasms; Cell Movement; Cell Proliferation; Endosomes; Female; Humans; MAP Kinase Signaling System; MCF-7 Cells; Neoplasm Invasiveness; Protein Binding; Protein Interaction Domains and Motifs; Protein Transport; ral GTP-Binding Proteins; ral Guanine Nucleotide Exchange Factor
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180432
• Institution: National University of Singapore

10.1038/cddis.2015.266