Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency

• Main Authors: Chen, H, Aksoy, I, Gonnot, F, Osteil, P, Aubry, M, Hamela, C, Rognard, C, Hochard, A, Voisin, S, Fontaine, E, Mure, M, Afanassieff, M, Cleroux, E, Guibert, S, Chen, J, Vallot, C, Acloque, H, Genthon, C, Donnadieu, C, De Vos, J, Sanlaville, D, Guérin, J.-F, Weber, M, Stanton, L.W, Rougeulle, C, Pain, B, Bourillot, P.-Y, Savatier, P
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: 4 [4 (1,3 benzodioxol 5 yl) 5 (2 pyridinyl) 1h imidazol 2 yl]benzamide; activin; activin receptor; cytochrome P450 1B1; DNA methyltransferase 1; DNA methyltransferase 3B; fibroblast growth factor 2; glycoprotein gp 130; hepatocyte nuclear factor 3beta; Janus kinase; kruppel like factor 2; kruppel like factor 4; kruppel like factor 5; leukemia inhibitory factor receptor; octamer transcription factor 4; STAT3 protein; suppressor of cytokine signaling 3; tamoxifen; transcription factor GATA 4; transcription factor GATA 6; transcription factor HoxA9; transcription factor NANOG; transcription factor Nkx2.5; leukemia inhibitory factor; LIF protein, human; STAT3 protein, human; embryo; enzyme activity; gene expression; germ cell; growth rate; hormone; ligand; signaling; animal cell; Article; cell differentiation; cell growth; cell renewal; cellular distribution; controlled study; ectoderm; embryonic stem cell; female; human; human cell; in vitro study; male; mouse; nonhuman; pluripotent stem cell; preimplantation embryo; protein expression; protein localization; protein phosphorylation; signal transduction; animal; cytology; drug effects; feeder cell; fibroblast; gene expression regulation; genetics; metabolism; physiology; protein microarray; Rodentia; Animals; Embryonic Stem Cells; Feeder Cells; Fibroblast Growth Factor 2; Fibroblasts; Gene Expression Regulation; Humans; Leukemia Inhibitory Factor; Mice; Pluripotent Stem Cells; Protein Array Analysis; Signal Transduction; STAT3 Transcription Factor; Tamoxifen
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180470
• Institution: National University of Singapore

10.1038/ncomms8095