Antigen 85C inhibition restricts Mycobacterium tuberculosis growth through disruption of cord factor biosynthesis

• Main Authors: Warrier, T, Tropis, M, Werngren, J, Diehl, A, Gengenbacher, M, Schlegel, B, Schade, M, Oschkinat, H, Daffe, M, Hoffner, S, Eddine, A.N, Kaufmann, S.H.E
• Other Authors: MEDICINE
• Format: Article
• Published: 2020
• Subjects: 2 amino 6 propyl 4,5,6,7 tetrahydro 1 benzothiophene 3 carbonitrile; antigen; antigen 85c; cord factor; protein inhibitor; unclassified drug; animal cell; antigen binding; antigen purification; article; bacterial growth; bacterial membrane; bacterial survival; bacterium culture; broth dilution; controlled study; lipogenesis; macrophage; membrane damage; mouse; Mycobacterium tuberculosis; nonhuman; nuclear magnetic resonance; priority journal; Acyltransferases; Animals; Antigens, Bacterial; Bone Marrow Cells; Cell Membrane Permeability; Cell Survival; Cord Factors; Culture Media; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Female; Lipids; Macrophages; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Oxazines; Recombinant Proteins; Thioglucosides; Uracil; Xanthenes
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180840
• Institution: National University of Singapore

10.1128/AAC.05742-11