Levosimendan inhibits release of reactive oxygen species in polymorphonuclear leukocytes in vitro and in patients with acute heart failure and septic shock: A prospective observational study

• Main Authors: Hasslacher, J, Bijuklic, K, Bertocchi, C, Kountchev, J, Bellmann, R, Dunzendorfer, S, Joannidis, M
• Other Authors: MECHANOBIOLOGY INSTITUTE
• Format: Article
• Published: 2020
• Subjects: dobutamine; formylmethionylleucylphenylalanine; levosimendan; noradrenalin; phorbol 13 acetate 12 myristate; reactive oxygen metabolite; cardiotonic agent; hydrazone derivative; pyridazine derivative; simendan; acute heart failure; adult; aged; apoptosis; article; clinical article; continuous infusion; controlled study; drug blood level; female; flow cytometry; heart hemodynamics; human; human cell; in vitro study; kidney function; male; neutrophil; observational study; priority journal; prospective study; protein expression; septic shock; acute disease; Austria; drug antagonism; drug effect; heart failure; middle aged; pathophysiology; Acute Disease; Aged; Aged, 80 and over; Cardiotonic Agents; Female; Flow Cytometry; Heart Failure; Humans; Hydrazones; Male; Middle Aged; Neutrophils; Prospective Studies; Pyridazines; Reactive Oxygen Species; Shock, Septic
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180856
• Institution: National University of Singapore

10.1186/cc10307