FoxM1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion

• Main Authors: Zheng, Y, Guo, J, Zhou, J, Lu, J, Chen, Q, Zhang, C, Qing, C, Koeffler, H.P, Tong, Y
• Other Authors: MEDICINE
• Format: Article
• Published: 2020
• Subjects: dickkopf 1 protein; forkhead transcription factor; forkhead transcription factor FOXM1; securin; unclassified drug; DKK1 protein, human; forkhead box protein M1; FOXM1 protein, human; pituitary tumor-transforming protein 1, human; signal peptide; Wnt protein; animal experiment; animal model; animal tissue; Article; bioinformatics; cell invasion; cell migration; chromatin immunoprecipitation; colorectal cancer; controlled study; female; gel mobility shift assay; gene expression regulation; gene function; gene identification; gene inactivation; gene silencing; gene targeting; HCT116 cell line; human; human cell; in vitro study; in vivo study; liver metastasis; microarray analysis; mouse; nonhuman; priority journal; promoter region; protein DNA binding; protein expression; protein function; PTTG1 gene; transcription regulation; upregulation; wild type; antagonists and inhibitors; cell motion; colorectal tumor; genetic transcription; genetics; HCT 116 cell line; liver tumor; metabolism; pathology; secondary; transcription initiation; tumor invasion; Cell Movement; Colorectal Neoplasms; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Intercellular Signaling Peptides and Proteins; Liver Neoplasms; Neoplasm Invasiveness; Promoter Regions, Genetic; Securin; Transcription, Genetic; Transcriptional Activation; Up-Regulation; Wnt Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/180901
• Institution: National University of Singapore

10.1186/s12920-015-0126-9